Results
Title

Gene–Environment Interaction in Alzheimer’s Disease.

Authors

Singh, Neeraj Kumar; Chhillar, Neelam; Banerjee, B. D.; Bala, Kiran; Mukherjee, Ajit Kumar; Mustafa, M. D.; Mitrabasu

Abstract

The article discusses a study to evaluate the gene environment (GxE) interaction observed in patients with Alzheimer's disease and the contribution of apolipoprotein E gene (APOE) polymorphism, serum lipids and organochlorine pesticides (OCPs)to the disease. The study concluded that GxE interactions do exist with APOE genotypes, and that serum cholesterol, b- hexachlorocyclohexane (b-HCH) and dieldrin are risk factors for Alzheimer's disease.

Subjects

INDIA; GENETICS of Alzheimer's disease; CHI-squared test; CONFIDENCE intervals; EPIDEMIOLOGY; GENES; GENETIC polymorphisms; POLYMERASE chain reaction; PROBABILITY theory; PSYCHOLOGICAL tests; SCALES (Weighing instruments); STATISTICS; T-test (Statistics); U-statistics; LOGISTIC regression analysis; DATA analysis; CASE-control method; DATA analysis software; DESCRIPTIVE statistics

Publication

American Journal of Alzheimer's Disease & Other Dementias, 2012, Vol 27, Issue 7, p496

ISSN

1533-3175

Publication type

Academic Journal

DOI

10.1177/1533317512456067