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- Title
Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab.
- Authors
Balshi, Alexandra; Manning, Nova; Dempsey, John; Kumbar, Sachin; Baber, Ursela; Sloane, Jacob A
- Abstract
Cases of herpes zoster (HZ) in patients with MS on natalizumab (NTZ) have been documented. In this study, we assessed lymphocyte subsets in NTZ-treated patients with HZ compared to matched controls without HZ. Twenty unvaccinated patients developed HZ while on NTZ for an incidence rate of 12.3 per 1000 patient-years. These patients had lower CD8+% and higher CD4+:CD8+ ratios (p ⩽ 0.01) than non-HZ matched controls. Two patients with relapsing-remitting MS developed HZ twice while on NTZ. These findings underscore the importance of pre-NTZ HZ vaccination due to potential HZ risk.
- Subjects
HERPES zoster; LYMPHOCYTE subsets; MULTIPLE sclerosis; NATALIZUMAB; VACCINATION status
- Publication
Multiple Sclerosis Journal, 2024, Vol 30, Issue 10, p1370
- ISSN
1352-4585
- Publication type
Academic Journal
- DOI
10.1177/13524585241260537