ABO Blood Group, SARS-CoV-2 Infection, and Risk of Venous Thromboembolism: Population-Based Cohort Study.

Ray, Joel G.; Vermeulen, Marian J.; Schull, Michael J.; Park, Alison L.

Non-O blood, blood group, SARS-CoV-2, COVID-19, pulmonary embolism, deep vein thrombosis, venous thromboembolism Keywords: non-O blood; blood group; SARS-CoV-2; COVID-19; pulmonary embolism; deep vein thrombosis; venous thromboembolism EN non-O blood blood group SARS-CoV-2 COVID-19 pulmonary embolism deep vein thrombosis venous thromboembolism 1 4 4 12/28/21 20210101 NES 210101 Persons with non-O blood group (i.e., A, AB or B) may be at higher risk of venous thromboembolism (VTE) than those with O blood (odds ratio 1.79, 95% CI 1.56 to 2.05).[1] Non-O blood groups may also be predisposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).[2] During the recent SARS-CoV-2 pandemic, a high rate of VTE was observed among infected patients.[3] Lung tissue specimens from coronavirus disease 2019 (COVID-19) patients showed a preponderance of alveolar capillary microthrombi.[4] A unique COVID-19-associated predisposing coagulopathy (CAC) was proposed.[5] It is not known whether SARS-CoV-2 infected patients with non-O blood groups are especially at higher risk of VTE. The aHR for PE was higher among non-O blood groups in patients without SARS-CoV-2 infection (1.33, 1.13 to 1.56), but not those with SARS-CoV-2 infection (1.14, 95% CI 0.56 to 2.31) (Table 2).

ABO blood group system; THROMBOEMBOLISM; PULMONARY embolism; SARS-CoV-2; COHORT analysis

Clinical & Applied Thrombosis/Hemostasis, 2021, Vol 27, p1

1076-0296

Academic Journal

10.1177/10760296211008986