Works matching DE "PREGNANE X receptor"

Results: 402

Revealing the Macromolecular Targets of Fragment-Like Natural Products.

Published in:

Angewandte Chemie, 2015, v. 127, n. 36, p. 10662, doi. 10.1002/ange.201504241

By:

Rodrigues, Tiago;
Reker, Daniel;
Kunze, Jens;
Schneider, Petra;
Schneider, Gisbert

Publication type:

Article

Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09471-z

By:

Carlson, Jennifer;
Neidviecky, Emma;
Cook, Isabel;
Cross, Bethany;
Deng, Huai

Publication type:

Article

Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer.

Published in:

Medicinal Research Reviews, 2020, v. 40, n. 3, p. 1061, doi. 10.1002/med.21648

By:

Chai, Sergio C.;
Wright, William C.;
Chen, Taosheng

Publication type:

Article

Two Apriona Species Sharing a Host Niche Have Different Gut Microbiome Diversity.

Published in:

Microbial Ecology, 2022, v. 83, n. 4, p. 1059, doi. 10.1007/s00248-021-01799-4

By:

Zhang, Shou-Ke;
Wang, Yi;
Li, Zi-Kun;
Xue, Huai-Jun;
Zhou, Xu-Dong;
Huang, Jun-Hao

Publication type:

Article

Functions of pregnane X receptor in self-detoxification.

Published in:

Amino Acids, 2017, v. 49, n. 12, p. 1999, doi. 10.1007/s00726-017-2435-0

By:

He, Liuqin;
Zhou, Xihong;
Huang, Niu;
Li, Huan;
Li, Tiejun;
Yao, Kang;
Tian, Yanan;
Hu, Chien-An;
Yin, Yulong

Publication type:

Article

Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression.

Published in:

Biochemical Journal, 2024, v. 481, n. 18, p. 1173, doi. 10.1042/BCJ20240172

By:

Takumi Sato;
Ryota Shizu;
Ryonosuke Baba;
Akira Ooka;
Takuomi Hosaka;
Yuichiro Kanno;
Kouichi Yoshinari

Publication type:

Article

Advances in drug resistance of osteosarcoma caused by pregnane X receptor.

Published in:

Drug Metabolism Reviews, 2024, v. 56, n. 4, p. 385, doi. 10.1080/03602532.2024.2366948

By:

Mao, Kunhong;
Liu, Can;
Tang, Zhongwen;
Rao, Zhouzhou;
Wen, Jie

Publication type:

Article

Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models.

Published in:

Drug Metabolism Reviews, 2023, v. 55, n. 4, p. 405, doi. 10.1080/03602532.2023.2254525

By:

El-Ghiaty, Mahmoud A.;
El-Mahrouk, Sara R.;
Alqahtani, Mohammed A.;
El-Kadi, Ayman O. S.

Publication type:

Article

Pregnane X receptor as a therapeutic target for cholestatic liver injury.

Published in:

Drug Metabolism Reviews, 2023, v. 55, n. 4, p. 371, doi. 10.1080/03602532.2023.2248680

By:

Lan, Huan;
Zhang, Ying;
Fan, Minqi;
Wu, Bingxin;
Wang, Caiyan

Publication type:

Article

Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms.

Published in:

Drug Metabolism Reviews, 2023, v. 55, n. 3, p. 239, doi. 10.1080/03602532.2023.2215478

By:

Ezhilarasan, Devaraj

Publication type:

Article

Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism.

Published in:

Drug Metabolism Reviews, 2022, v. 54, n. 1, p. 46, doi. 10.1080/03602532.2022.2039688

By:

Stanley, Lesley A.;
Wolf, C. Roland

Publication type:

Article

Implication of metabolomics and transporter modulation based strategies to minimize multidrug resistance and enhance site-specific bioavailability: a needful consideration toward modern anticancer drug discovery.

Published in:

Drug Metabolism Reviews, 2022, v. 54, n. 2, p. 101, doi. 10.1080/03602532.2022.2048007

By:

Rachmale, Megha;
Rajput, Niraj;
Jadav, Tarang;
Sahu, Amit Kumar;
Tekade, Rakesh K.;
Sengupta, Pinaki

Publication type:

Article

Sulfotransferase genes: Regulation by nuclear receptors in response to xeno/endo-biotics.

Published in:

Drug Metabolism Reviews, 2013, v. 45, n. 4, p. 441, doi. 10.3109/03602532.2013.835630

By:

Kodama, Susumu;
Negishi, Masahiko

Publication type:

Article

Pregnane X receptor activation induces liver enlargement and regeneration and simultaneously promotes the metabolic activity of CYP3A1/2 and CYP2C6/11 in rats.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2024, v. 135, n. 2, p. 148, doi. 10.1111/bcpt.14041

By:

Bi, Guofang;
Liang, Fengting;
Wu, Ting;
Wang, Peng;
Jiang, Xiaowen;
Hu, Shuang;
Wu, Chenghua;
Zhou, Wenhong;
Guo, Jiayin;
Yang, Xiao;
Fang, Jian‐hong;
Chen, Wenying;
Bi, Huichang

Publication type:

Article

Effects of rifampicin on porphyrin metabolism in healthy volunteers.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2023, v. 132, n. 3, p. 281, doi. 10.1111/bcpt.13826

By:

Tolonen, Hanna;
Ranta, Sirpa;
Hämäläinen, Esa;
Kauppinen, Raili;
Hukkanen, Janne

Publication type:

Article

Rifampicin induces the bone form of alkaline phosphatase in humans.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 130, p. 81, doi. 10.1111/bcpt.13586

By:

Nabil, Heba;
Kummu, Outi;
Lehenkari, Petri;
Rysä, Jaana;
Risteli, Juha;
Hakkola, Jukka;
Hukkanen, Janne

Publication type:

Article

Translational pharmacology: Closing the mechanistic gap.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 130, p. 3, doi. 10.1111/bcpt.13693

By:

Pottegård, Anton;
Stage, Tore B.

Publication type:

Article

Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2018, v. 123, p. 42, doi. 10.1111/bcpt.13004

By:

Hakkola, Jukka;
Bernasconi, Camilla;
Coecke, Sandra;
Richert, Lysiane;
Andersson, Tommy B.;
Pelkonen, Olavi

Publication type:

Article

Effect of pregnane X receptor expression on drug resistance in breast cancer.

Published in:

Oncology Letters, 2014, v. 7, n. 4, p. 1191, doi. 10.3892/ol.2014.1817

By:

EN-QI QIAO;
HONG-JIAN YANG

Publication type:

Article

Atlantic Salmon Gill Epithelial Cell Line (ASG-10) as a Suitable Model for Xenobiotic Biotransformation.

Published in:

Metabolites (2218-1989), 2023, v. 13, n. 6, p. 771, doi. 10.3390/metabo13060771

By:

Ivanova, Lada;
Fæste, Christiane Kruse;
Solhaug, Anita

Publication type:

Article

The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism.

Published in:

Metabolites (2218-1989), 2023, v. 13, n. 5, p. 629, doi. 10.3390/metabo13050629

By:

Haduch, Anna;
Bromek, Ewa;
Kuban, Wojciech;
Daniel, Władysława Anna

Publication type:

Article

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 6, p. 528, doi. 10.3390/metabo12060528

By:

Lefever, Daniel E.;
Miedel, Mark T.;
Pei, Fen;
DiStefano, Johanna K.;
Debiasio, Richard;
Shun, Tong Ying;
Saydmohammed, Manush;
Chikina, Maria;
Vernetti, Lawrence A.;
Soto-Gutierrez, Alejandro;
Monga, Satdarshan P.;
Bataller, Ramon;
Behari, Jaideep;
Yechoor, Vijay K.;
Bahar, Ivet;
Gough, Albert;
Stern, Andrew M.;
Taylor, D. Lansing

Publication type:

Article

Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 2, p. N.PAG, doi. 10.3390/metabo12020095

By:

Shioda, Keiko;
Odajima, Junko;
Blumberg, Bruce;
Shioda, Toshi

Publication type:

Article

Molecular Mechanisms of the SLC13A5 Gene Transcription.

Published in:

Metabolites (2218-1989), 2021, v. 11, n. 10, p. 706, doi. 10.3390/metabo11100706

By:

Li, Zhihui;
Wang, Hongbing

Publication type:

Article

Importance of Pharmacogenetics and Drug–Drug Interactions in a Kidney Transplanted Patient.

Published in:

Life (2075-1729), 2023, v. 13, n. 8, p. 1627, doi. 10.3390/life13081627

By:

Concha, Julia;
Sangüesa, Estela;
Saez-Benito, Ana M.;
Aznar, Ignacio;
Berenguer, Nuria;
Saez-Benito, Loreto;
Ribate, M. Pilar;
García, Cristina B.

Publication type:

Article

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.574176

By:

Duan, Ya-bin;
Zhu, Jun-bo;
Yang, Jian-xin;
Liu, Gui-qin;
Bai, Xue;
Qu, Ning;
Wang, Xue-jun;
Li, Xiang-yang

Publication type:

Article

The Clinical Impact of the C<sub>0</sub>/D Ratio and the CYP3A5 Genotype on Outcome in Tacrolimus Treated Kidney Transplant Recipients.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.01142

By:

van Gelder, Teun;
Meziyerh, Soufian;
Swen, Jesse J.;
de Vries, Aiko P. J.;
Moes, Dirk Jan A. R.

Publication type:

Article

Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00474

By:

Yu, Zhilun;
Yue, Bei;
Ding, Lili;
Luo, Xiaoping;
Ren, Yijing;
Zhang, Jingjing;
Mani, Sridhar;
Wang, Zhengtao;
Dou, Wei

Publication type:

Article

Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.942027

By:

Yukun Huang;
Lu Liu;
Zhenyu Hao;
Lingna Chen;
Qian Yang;
Xia Xiong;
Yongqiong Deng

Publication type:

Article

Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.846555

By:

Koduru, Lokanand;
Lakshmanan, Meiyappan;
Hoon, Shawn;
Lee, Dong-Yup;
Lee, Yuan Kun;
Ow, Dave Siak-Wei

Publication type:

Article

Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.761067

By:

Al Bataineh, Mohammad Tahseen;
Henschel, Andreas;
Mousa, Mira;
Daou, Marianne;
Waasia, Fathimathuz;
Kannout, Hussein;
Khalili, Mariam;
Kayasseh, Mohd Azzam;
Alkhajeh, Abdulmajeed;
Uddin, Maimunah;
Alkaabi, Nawal;
Tay, Guan K.;
Feng, Samuel F.;
Yousef, Ahmed F.;
Alsafar, Habiba S.

Publication type:

Article

Tryptophan Co-Metabolism at the Host-Pathogen Interface.

Published in:

Frontiers in Immunology, 2020, p. 1, doi. 10.3389/fimmu.2020.00067

By:

Costantini, Claudio;
Bellet, Marina M.;
Renga, Giorgia;
Stincardini, Claudia;
Borghi, Monica;
Pariano, Marilena;
Cellini, Barbara;
Keller, Nancy;
Romani, Luigina;
Zelante, Teresa

Publication type:

Article

Editorial: Endocrine Disruptors in Aquatic Vertebrates.

Published in:

2021

By:

Moreira, Renata Guimarães;
Carnevali, Oliana;
Lo Nostro, Fabiana Laura

Publication type:

Editorial

A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2021.665521

By:

Creusot, Nicolas;
Garoche, Clémentine;
Grimaldi, Marina;
Boulahtouf, Abdelhay;
Chiavarina, Barbara;
Bourguet, William;
Balaguer, Patrick

Publication type:

Article

The Preservation of PPAR γ Genome Duplicates in Some Teleost Lineages: Insights into Lipid Metabolism and Xenobiotic Exploitation.

Published in:

Genes, 2022, v. 13, n. 1, p. 107, doi. 10.3390/genes13010107

By:

Páscoa, Inês;
Fonseca, Elza;
Ferraz, Renato;
Machado, André M.;
Conrado, Francisca;
Ruivo, Raquel;
Cunha, Isabel;
Castro, Luís Filipe C.

Publication type:

Article

Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics.

Published in:

Genes, 2020, v. 11, n. 12, p. 1509, doi. 10.3390/genes11121509

By:

de Jong, Laura M.;
Jiskoot, Wim;
Swen, Jesse J.;
Manson, Martijn L.

Publication type:

Article

Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1.

Published in:

Journal of Biomedical Research, 2023, v. 37, n. 6, p. 431, doi. 10.7555/JBR.37.20230047

By:

Minqin Xu;
Lihua Zhang;
Lan Lin;
Zhiyi Qiang;
Wei Liu;
Jian Yang

Publication type:

Article

miR-3609 Decelerates the Clearance of Sorafenib in Hepatocellular Carcinoma Cells by Targeting EPAS-1 and Reducing the Activation of the Pregnane X Receptor Pathway.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 7213, doi. 10.2147/OTT.S246471

By:

Shao, Qing-Ping;
Wei, Chen;
Yang, Jie;
Zhang, Wen-Zhou

Publication type:

Article

Proteomics based drug repositioning applied to improve in vitro fertilization implantation: an artificial intelligence model.

Published in:

Systems Biology in Reproductive Medicine, 2021, v. 67, n. 4, p. 281, doi. 10.1080/19396368.2021.1928792

By:

Matorras, Roberto;
Valls, Raquel;
Azkargorta, Mikel;
Burgos, Jorge;
Rabanal, Aintzane;
Elortza, Felix;
Mas, Jose Manuel;
Sardon, Teresa

Publication type:

Article

Assessment of cytochrome P450 induction in canine intestinal organoid models.

Published in:

Xenobiotica, 2024, v. 54, n. 5, p. 217, doi. 10.1080/00498254.2024.2326973

By:

Nagao, Itsuma;
Nakazawa, Meg;
Goyama, Takashi;
Court, Michael H.;
Ambrosini, Yoko M.

Publication type:

Article

Hyperoside ameliorates cisplatin-induced acute kidney injury by regulating the expression and function of Oat1.

Published in:

Xenobiotica, 2023, v. 53, n. 8/9, p. 559, doi. 10.1080/00498254.2023.2270046

By:

Wenjing Yuan;
Shanshan Kou;
Ying Ma;
Yusi Qian;
Xinyu Li;
Yuanyuan Chai;
Zhenzhou Jiang;
Luyong Zhang;
Lixin Sun;
Xin Huang

Publication type:

Article

Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2.

Published in:

Xenobiotica, 2022, v. 52, n. 4, p. 389, doi. 10.1080/00498254.2022.2079441

By:

Li, Yuhua;
Liao, Zhengzheng;
Wei, Xiaohua;
Xiao, Xiong;
Hu, Jinfang

Publication type:

Article

A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.

Published in:

Xenobiotica, 2021, v. 51, n. 7, p. 752, doi. 10.1080/00498254.2021.1918800

By:

Li, Han;
Wang, Yu-Guang;
Ma, Zeng-Chun;
Yun-Hang, Gao;
Ling, Song;
Teng-Fei, Chen;
Guang-Ping, Zhang;
Gao, Yue

Publication type:

Article

Effects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line.

Published in:

Xenobiotica, 2020, v. 50, n. 9, p. 1043, doi. 10.1080/00498254.2020.1737760

By:

Wang, Zhenyue;
Liu, Yongtao;
Ai, Xiaohui;
Zhong, Liqiao;
Han, Gang;
Song, Jinlong;
Yang, Qiuhong;
Dong, Jing

Publication type:

Article

Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system.

Published in:

Xenobiotica, 2020, v. 50, n. 6, p. 654, doi. 10.1080/00498254.2019.1683258

By:

Taniguchi, Mariko;
Miyamoto, Hirotaka;
Tokunaga, Ayako;
Fumoto, Shintaro;
Tanaka, Takashi;
Nishida, Koyo

Publication type:

Article

Porcine interleukin-6 enhances the expression of CYP2C33 through a constitutive androstane receptor/retinoid X receptor-mediated pathway.

Published in:

Xenobiotica, 2019, v. 49, n. 3, p. 257, doi. 10.1080/00498254.2018.1438686

By:

Xie, Lixia;
He, Yucheng;
Zhou, Xiaoqiao;
Li, Xiaowen;
Jin, Xiue;
Wang, Xiliang;
Shi, Deshi

Publication type:

Article

Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice.

Published in:

Xenobiotica, 2018, v. 48, n. 11, p. 1098, doi. 10.1080/00498254.2017.1400128

By:

Yamasaki, Yuki;
Kobayashi, Kaoru;
Inaba, Asumi;
Uehara, Daisuke;
Tojima, Hiroki;
Kakizaki, Satoru;
Chiba, Kan

Publication type:

Article

Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.

Published in:

Xenobiotica, 2018, v. 48, n. 7, p. 647, doi. 10.1080/00498254.2017.1353163

By:

Moscovitz, Jamie E.;
Lin, Zhiwu;
Johnson, Nathaniel;
Tu, Meihua;
Goosen, Theunis C.;
Weng, Yan;
Kalgutkar, Amit S.

Publication type:

Article

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.

Published in:

Nature Medicine, 2013, v. 19, n. 4, p. 418, doi. 10.1038/nm.3104

By:

Li, Feng;
Lu, Jie;
Cheng, Jie;
Wang, Laiyou;
Matsubara, Tsutomu;
Csanaky, Iván L;
Klaassen, Curtis D;
Gonzalez, Frank J;
Ma, Xiaochao

Publication type:

Article

Dose-dependent difference of nuclear receptors involved in murine liver hypertrophy by piperonyl butoxide.

Published in:

Journal of Toxicological Sciences, 2015, v. 40, n. 6, p. 787, doi. 10.2131/jts.40.787

By:

Yohei Sakamoto;
Midori Yoshida;
Kei Tamura;
Miwa Takahashi;
Yukio Kodama;
Kaoru Inoue

Publication type:

Article