Title: Cancer Therapeutic Potential and Prognostic Value of the SLC25 Mitochondrial Carrier Family: A Review.
Authors: Gao, Renzhuo; Zhou, Dan; Qiu, Xingpeng; Zhang, Jiayi; Luo, Daya; Yang, Xiaohong; Qian, Caiyun; Liu, Zhuoqi
Abstract: Transporters of the solute carrier family 25 (SLC25) regulate the intracellular distribution and concentration of nucleotides, amino acids, dicarboxylates, and vitamins within the mitochondrial and cytoplasmic matrices. This mechanism involves changes in mitochondrial function, regulation of cellular metabolism, and the ability to provide energy. In this review, important members of the SLC25 family and their pathways affecting tumorigenesis and progression are elucidated, highlighting the diversity and complexity of these pathways. Furthermore, the significant potential of the members of SLC25 as both cancer therapeutic targets and biomarkers will be emphasized.
Publication: Cancer Control: Journal of the Moffitt Cancer Center, 2024, p1
ISSN: 1073-2748
Publication type: Academic Journal
DOI: 10.1177/10732748241287905

Cancer Therapeutic Potential and Prognostic Value of the SLC25 Mitochondrial Carrier Family: A Review.

Gao, Renzhuo; Zhou, Dan; Qiu, Xingpeng; Zhang, Jiayi; Luo, Daya; Yang, Xiaohong; Qian, Caiyun; Liu, Zhuoqi