Prophylactic Use of Steroids and Antibiotics in Acute Hydrocarbon Poisoning in Children.

Das, Saibal; Behera, Sapan Kumar; Xavier, Alphienes Stanley; Selvarajan, Sandhiya

Ingestion of hydrocarbons is a common cause of childhood poisoning in low and middle-income countries. Although mild ingestions are usually devoid of complications, the morbidity and mortality associated with such poisoning are primarily related to pulmonary aspiration. Subsequent complications, most importantly, secondary bacterial infections can worsen the clinical condition. Standard treatment protocol for acute accidental hydrocarbon poisoning does not advocate routine use of steroids or antibiotics. However, some studies have demonstrated beneficial effects of prophylactic steroid and antibiotic to prevent chemical pneumonitis. In this article, we have summarized the findings of the clinical studies from literature, which have evaluated the advantages of early administration of steroids and antibiotics to prevent chemical pneumonitis in acute hydrocarbon poisoning in children. From these studies, we have found that there is no convincing evidence for initiating steroid and antibiotic to improve outcome in these children.

ANTIBIOTICS; PNEUMONIA prevention; STEROID drugs; HYDROCARBONS; PNEUMONIA; PREVENTIVE health services; TREATMENT effectiveness; EARLY medical intervention; MIDDLE-income countries; LOW-income countries; CHILDREN

Journal of Pharmacy Practice, 2020, Vol 33, Issue 1, p90

0897-1900

Academic Journal

10.1177/0897190018771520