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- Title
Alginate hydrogel enriched with Ambystoma mexicanum epidermal lipoxygenase-loaded pectin nanoparticles for enhanced wound healing.
- Authors
Oveissi, Farnoush; Tavakoli, Naser; Minaiyan, Mohsen; Mofid, Mohammad Reza; Taheri, Azade
- Abstract
Epidermal lipoxygenase enzyme extracted from Ambystoma mexicanum (AmbLOXe) is known to accelerate the wound-healing process. AmbLOXe as a protein suffers from inactivation and losing its activity during formulation. Therefore, a delivery system that protects AmbLOXe from inactivation and preserves its activity is needed. We prepared AmbLOXe-loaded pectin nanoparticles (AmbLOXe Pec-NPs) and placed them into an alginate hydrogel. AmbLOXe Pec-NPs incorporation into the alginate hydrogel provides a means for controlled and sustained delivery of AmbLOXe to the wound site. Furthermore, the suitable swelling behavior and mechanical properties of AmbLOXe Pec-NPs alginate hydrogel make it feasible for clinical use. AmbLOXe Pec-NPs alginate hydrogel significantly enhanced the wound-healing process on the rat full-thickness excisional wounds, increased the rate of wound closure, enhanced the re-epithelialization and decreased the incidence of abnormal scarring. AmbLOXe Pec-NPs alginate hydrogel can be proposed as an effective wound hydrogel for improving wound healing with minimal scarring.
- Subjects
ALGINIC acid; WOUND healing; NANOPARTICLES; ALGINATES; OINTMENTS; PECTINS; SCARS
- Publication
Journal of Biomaterials Applications, 2020, Vol 34, Issue 8, p1171
- ISSN
0885-3282
- Publication type
Academic Journal
- DOI
10.1177/0885328219896704