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- Title
Local administration with silymarin could increase osseointegration of hydroxyapatite-coated titanium implants in ovariectomized rats.
- Authors
Tao, Zhou-Shan; Wu, Xing-Jing; Yang, Min; Xu, Hong-Guang
- Abstract
As hydroxyapatite has good osteoconductive properties, it is used as coating material for the implants in cementless arthroplasty. However, its effect is not sufficient for osteoporotic bone. Silymarin promotes osteoblast proliferation and inhibits osteoclast proliferation, and positively affects bone regeneration. System administration of silymarin increases bone strength and both cancellous and cortical bone mass. The aim of this study was to confirm the effect of the local incorporation silymarin into hydroxyapatite-coated titanium implants in the osteoporotic and normal condition. Twelve-week-old female Sprague-Dawley rats were used for this study. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into three groups: group sham, group ovariectomized and group silymarin, and the rats from ovariectomized and sham received hydroxyapatite implants and animals belong to group silymarin received silymarin-hydroxyapatite implants until death at 12 weeks, respectively. The bilateral femurs of rats were harvested for evaluation. All treatments increased new bone formation around the surface of titanium rods and push-out force other than group ovariectomized. Compared with group ovariectomized, group silymarin showed the strongest effects on new bone formation, biomechanical strength and regulation of osteogenesis and bone resorption-related gene expression, respectively. Additionally, these are significant difference in bone formation, gene expression and push-out force was observed among treatment groups. This finding suggests that local incorporation of silymarin is useful to improve the fixation of hydroxyapatite-coated implants in ovariectomized rats.
- Subjects
OSSEOINTEGRATION; SILYMARIN; LOCAL government; COMPACT bone; TITANIUM; CANCELLOUS bone; HYDROXYAPATITE
- Publication
Journal of Biomaterials Applications, 2019, Vol 34, Issue 5, p664
- ISSN
0885-3282
- Publication type
Academic Journal
- DOI
10.1177/0885328219863290