EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Ectopic Bone Formation from Mandibular Osteoblasts Cultured in a Novel Human Serum-derived Albumin Scaffold.

Authors

Gallego, Lorena; Junquera, Luis; Meana, Álvaro; Álvarez-Viejo, Mariá; Fresno, Manuel

Abstract

The aim of this study was to evaluate the ectopic bone formation using a novel serum-derived albumin scaffold and cultured human mandibular osteoblasts in nude mice. Osteoblasts were cultured with 10% human serum and plated in a novel spongy noncalcified protein scaffold prepared with plasmatic albumin crossed with a glutaraldehyde type agent. Hematoxylin-eosin staining revealed a bone-like extracellular matrix and in vitro mineralization was confirmed by von Kossa staining. Histological and immunohistochemical evaluation showed progression of mineralization in vivo. These results suggest the clinical feasibility of alveolar cells and albumin scaffold as a good alternative for bone regeneration.

Subjects

BONE growth; BONE regeneration; ECTOPIC tissue; OSTEOCLASTS; SERUM albumin; TISSUE scaffolds; TISSUE engineering; EXTRACELLULAR matrix

Publication

Journal of Biomaterials Applications, 2010, Vol 25, Issue 4, p367

ISSN

0885-3282

Publication type

Academic Journal

DOI

10.1177/0885328209353643

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved