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- Title
Ectopic Bone Formation from Mandibular Osteoblasts Cultured in a Novel Human Serum-derived Albumin Scaffold.
- Authors
Gallego, Lorena; Junquera, Luis; Meana, Álvaro; Álvarez-Viejo, Mariá; Fresno, Manuel
- Abstract
The aim of this study was to evaluate the ectopic bone formation using a novel serum-derived albumin scaffold and cultured human mandibular osteoblasts in nude mice. Osteoblasts were cultured with 10% human serum and plated in a novel spongy noncalcified protein scaffold prepared with plasmatic albumin crossed with a glutaraldehyde type agent. Hematoxylin-eosin staining revealed a bone-like extracellular matrix and in vitro mineralization was confirmed by von Kossa staining. Histological and immunohistochemical evaluation showed progression of mineralization in vivo. These results suggest the clinical feasibility of alveolar cells and albumin scaffold as a good alternative for bone regeneration.
- Subjects
BONE growth; BONE regeneration; ECTOPIC tissue; OSTEOCLASTS; SERUM albumin; TISSUE scaffolds; TISSUE engineering; EXTRACELLULAR matrix
- Publication
Journal of Biomaterials Applications, 2010, Vol 25, Issue 4, p367
- ISSN
0885-3282
- Publication type
Academic Journal
- DOI
10.1177/0885328209353643