Reactive oxygen species induce cell death via Akt signaling in rat osteoblast-like cell line ROS 17/2.8.

Zhang, Bo; Xie, Qing-yun; Quan, Yi; Pan, Xian-ming; Liao, Dong-fa

In bones, osteoblasts are responsible for bone formation. The cell death of osteoblasts may cause a series of bone diseases and lead to bone loss, such as osteoarthrosis, hyperparathyroidism, and Paget’s disease. Reactive oxygen species (ROS) are reported as a main factor for osteoblast cell death and further several bone diseases. However, the detailed mechanism is still largely unknown. Here, we found that ROS could induce cell death of rat osteoblast-like cell line ROS 17/2.8 via Akt (protein kinase B). Also, the mammalian target of rapamycin signaling was involved in this process. Our findings could help to reveal the cellular mechanism of osteoblast cell death, which is served for the pursuit of clinical treatment targets of relative bone diseases.

REACTIVE oxygen species; CELL death; CELLULAR signal transduction; OSTEOBLASTS; CELL lines; LABORATORY rats

Toxicology & Industrial Health, 2015, Vol 31, Issue 12, p1236

0748-2337

Academic Journal

10.1177/0748233713491801