On the benefit of magnetic magnesium nanocarrier in cardiovascular toxicity of aluminum phosphide.

Baeeri, Maryam; Shariatpanahi, Marjan; Baghaei, Amir; Ghasemi-Niri, Seyedeh Farnaz; Mohammadi, Hamidreza; Mohammadirad, Azadeh; Hassani, Shokoufeh; Bayrami, Zahra; Hosseini, Asieh; Rezayat, Seyed Mahdi; Abdollahi, Mohammad

The present study was designed to determine the effect of a new 25Mg2 -carrying nanoparticle (25MgPMC16) on energy depletion, oxidative stress, and electrocardiographic (ECG) parameters on heart tissue of the rats poisoned by aluminum phosphide (AlP). 25MgPMC16 at doses of 0.025, 0.05, and 0.1 median lethal dose (LD50 = 896 mg/kg) was administered intravenously (iv) 30 min after a single intragastric administration of AlP (0.25 LD50). Sodium bicarbonate (Bicarb; 2 mEq/kg, iv) was used as the standard therapy. After anesthesia, the animals were rapidly connected to an electronic cardiovascular monitoring device for monitoring of ECG, blood pressure (BP), and heart rate (HR). Later lipid peroxidation, antioxidant power, ATP/ADP ratio, and Mg concentration in the heart were evaluated. Results indicated that after AlP administration, BP and HR decreased while R-R duration increased. 25MgPMC16 significantly increased the BP and HR at all doses used. We found a considerable increase in antioxidant power, Mg level in the plasma and the heart and a reduction in lipid peroxidation and ADP/ATP ratio at various doses of 25MgPMC16, but 25MgPMC16-0.025 Bicarb was the most effective combination therapy. The results of this study support that 25MgPMC16 can increase heart energy by active transport of Mg inside the cardiac cells.25MgPMC16 seems ameliorating AlP-induced toxicity and cardiac failure necessitating further studies.

MAGNESIUM; MAGNETIC materials; ALUMINUM phosphide; METAL toxicology; NANOPARTICLES; CARDIOVASCULAR system; OXIDATIVE stress; ELECTROCARDIOGRAPHY; LIPID peroxidation (Biology)

Toxicology & Industrial Health, 2013, Vol 29, Issue 2, p126

0748-2337

Academic Journal

10.1177/0748233711425074