This article develops a framework to demonstrate how employee job satisfaction influences entrepreneurial intentions. Based on new institutional theory, we examine our hypotheses using data from 39,394 employees from 27 countries; the results indicate that job satisfaction has a negative effect on entrepreneurial intentions moderated by uncertainty avoidance at the country level. Furthermore, a cross-level three-way interaction indicates that entrepreneurship legitimacy is an important climate-level variable that influences the entrepreneurial intentions of employees. We conclude by discussing the implications of our findings and future research directions.