Works matching IS 01926233 AND DT 2021 AND VI 49 AND IP 2

Results: 13

Inspiration and Exasperation: The Challenges of Inhaled Biologics.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 232, doi. 10.1177/0192623320984715

By:

Hall, Peter;
Vahle, John L.;
Colman, Karyn

Publication type:

Article

Review of the Technical, Toxicological, and PKPD Considerations for Conducting Inhalation Toxicity Studies on Biologic Pharmaceuticals—The Outcome of a Cross-Industry Working Group Survey.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 261, doi. 10.1177/0192623321988841

By:

Wolfreys, Alison;
Kilgour, Jo;
Allen, Andrew D.;
Dudal, Sherri;
Freke, Mark;
Jones, David;
Karantabias, George;
Krantz, Carsten;
Moore, Simon;
Mukaratirwa, Sidney;
Price, Mark;
Tepper, Jeffrey;
Cauvin, Annick;
Manetz, Scott;
Robinson, Ian

Publication type:

Article

BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 235, doi. 10.1177/0192623320976094

By:

Hall, A. Peter;
Tepper, Jeffrey S.;
Boyle, Molly H.;
Cary, Maurice G.;
Flandre, Thierry G.;
Piaia, Alessandro;
Tarnow, Inge;
Macri, Nicholas P.;
Freke, Mark C.;
Nikula, Kristen J.;
Paul, Graham R.;
Cauvin, Annick;
Gregori, Michela;
Haworth, Richard;
Naylor, Stuart;
Price, Mark;
Robinson, Ian N.;
Allen, Andrew;
Gelzleichter, Tom;
Hohlbaum, Andreas M.

Publication type:

Article

Preclinical Safety Assessment of 2 Inhaled Single-Domain Antibodies in the Cynomolgus Monkey.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 296, doi. 10.1177/0192623320972387

By:

Haworth, Richard;
Boyle, Molly;
Edwards, Paul;
Gupta, Reenu;
Fagg, Rajni;
Karantabias, George;
Price, Mark

Publication type:

Article

Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 334, doi. 10.1177/0192623320960420

By:

Greene, Stephanie F.;
Nikula, Kristen J.;
Poulin, Dominic;
McInally, Kevin;
Reynolds, Jack A.

Publication type:

Article

Case Studies Discussing the Pathology, Immunogenicity, and Proposed Mechanism of Toxicity of an Inhaled Anti-TGFβ Humanized Fab Antibody in Non-Human Primates and Mice.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 315, doi. 10.1177/0192623320960023

By:

Hall, Anthony Peter;
Cauvin, Annick;
Dudal, Sherri;
Raymond, James;
Rogerson, Petrina;
Jolette, Jacquelin

Publication type:

Article

Multisite Analysis of Lesions in the Respiratory Tract of the Rat and Nonhuman Primate (Cynomolgus Monkey) Exposed to Air, Vehicle, and Inhaled Small Molecule Compounds.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 349, doi. 10.1177/0192623320953839

By:

Gregori, Michela;
Naylor, Stuart W.;
Freke, Mark C.;
Chamanza, Ronnie;
Piaia, Alessandro;
Hall, A. Peter

Publication type:

Article

Biologic Immunomodulatory Drugs and Infection in the Respiratory Tract of Nonhuman Primates.

Published in:

2021

By:

Flandre, Thierry D.;
Piaia, Alessandro;
Cary, Maurice G.

Publication type:

Literature Review

Perspectives on Lung Dose and Inhaled Biomolecules.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 378, doi. 10.1177/0192623320946297

By:

Wolff, Ronald K.

Publication type:

Article

Nonclinical Safety Assessment of an Inhaled Formulation of Serelaxin: A Recombinant Human Protein in Rats and Cynomolgus Monkeys (Macaca fascicularis).

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 286, doi. 10.1177/0192623320943129

By:

Flandre, Thierry D.;
Hey, Adam S.;
Spence, Fiona J.

Publication type:

Article

Perspective on Adversity in Toxicology Evaluations.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 408, doi. 10.1177/0192623320941791

By:

Engelhardt, Jeffery A.;
Dorato, Michael A.

Publication type:

Article

Aspiration and Inspiration: Using Bronchoalveolar Lavage for Toxicity Assessment.

Published in:

2021

By:

Poitout-Belissent, Florence;
Grant, Shawn N.;
Tepper, Jeffrey S.

Publication type:

Literature Review

Epithelial Alteration Associated With Recovery From Laryngeal Squamous Metaplasia in Rats: Kinetics of Recovery From a Test Item-Related Change.

Published in:

Toxicologic Pathology, 2021, v. 49, n. 2, p. 370, doi. 10.1177/0192623320924655

By:

Macri, Nicholas P.;
Keenan, Charlotte M.;
Hoffman, Gary M.;
Cracknell, Stuart;
Schofield, Mike;
Bond, Andrew

Publication type:

Article