Works matching DE "DRUG development"

Results: 5000

Advances on cancer vaccine trials registered in China and the USA in 2014-2024.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1557253

By:

Shi, Wei;
Chen, Zhuo;
Yu, Qin;
Zhang, Lingli

Publication type:

Article

Development and Validation of a Robust LC-MS/MS Method for Quantitation of a Novel Kinase Inhibitor, Ritlecitinib, in Rat Plasma: Application in Pharmacokinetic Study.

Published in:

Journal of Pharmacology & Pharmacotherapeutics, 2025, v. 16, n. 3, p. 302, doi. 10.1177/0976500X241289642

By:

Kumar, Katari Pavan;
Rao, Areti Anka

Publication type:

Article

Applying Machine Learning Techniques to Predict Drug-Related Side Effect: A Policy Brief.

Published in:

Inquiry (00469580), 2025, v. 62, p. 1, doi. 10.1177/00469580251335805

By:

Toni, Esmaeel;
Ayatollahi, Haleh

Publication type:

Article

Evaluation of the α-amylase, α-glucosidase, and tyrosinase inhibitory and photoprotective activities of organic solvent and aqueous Extracts of Retama monosperma stem.

Published in:

Tropical Journal of Natural Product Research, 2025, v. 9, n. 5, p. 2357, doi. 10.26538/tjnpr/v9i5.66

By:

Benkhouili, Fatima Zahra;
Moutawalli, Amina;
Benzeid, Hanane;
Doukkali, Anass;
Zahidi, Ahmed

Publication type:

Article

Antirheumatic Potential of Araucaria-Derived Biflavonoids through In Silico Docking to 20S Proteasome.

Published in:

Tropical Journal of Natural Product Research, 2025, v. 9, n. 5, p. 2043, doi. 10.26538/tjnpr/v9i5.24

By:

Irfana, Luthfan;
Suryawan, Chinesia P.;
Arifin, Budi;
Achmadi, Suminar S.;
Wahyudi, Setyanto T.;
Sugita, Purwantiningsih

Publication type:

Article

The Premise of the Paradox: Examining the Evidence That Motivated GIPR Agonist and Antagonist Drug Development Programs.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 11, p. 3812, doi. 10.3390/jcm14113812

By:

Douros, Jonathan D.;
Mowery, Stephanie A.;
Knerr, Patrick J.

Publication type:

Article

Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.

Published in:

Clinical Pharmacokinetics, 2025, v. 64, n. 6, p. 865, doi. 10.1007/s40262-025-01513-4

By:

Tian, Zhiteng;
Luo, Hui;
Chu, Yantao;
Liu, Yanhong;
Gao, Shan;
Song, Ling;
Yang, Zhenzhen;
Liu, Dongyang

Publication type:

Article

槲皮素防治肝细胞癌相关信号通路研究进展.

Published in:

Evaluation & Analysis of Drug-Use in Hospitals of China / Zhongguo Yiyuan Yongyao Pingjia yu Fenxi, 2025, v. 25, n. 5, p. 632, doi. 10.14009/j.issn.1672-2124.2025.05.025

By:

姚三飞;
刘江凯

Publication type:

Article

A State-of-the-Art Review on Recent Biomedical Application of Polysaccharide-Based Niosomes as Drug Delivery Systems.

Published in:

Polymers (20734360), 2025, v. 17, n. 11, p. 1566, doi. 10.3390/polym17111566

By:

Iacob, Andreea-Teodora;
Ababei-Bobu, Andra;
Chirliu, Oana-Maria;
Lupascu, Florentina Geanina;
Vasincu, Ioana-Mirela;
Apotrosoaei, Maria;
Profire, Bianca-Stefania;
Tauser, Georgiana-Roxana;
Lupascu, Dan;
Profire, Lenuta

Publication type:

Article

Anti-Inflammatory Potential of Essential Oil from the Heart-Wood of the Folk Medicinal Tree Cinnamomum kanehirai Hayata in Macrophages.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5419, doi. 10.3390/ijms26115419

By:

Liu, May-Lan;
Liu, Pang-Yen;
Chao, Louis Kuoping;
Yang, Tzu-Jung;
Li, Lan-Hui;
Weng, Yih-Ming;
Sommano, Sarana Rose;
Unpaprom, Yuwalee;
Ramaraj, Rameshprabu;
Ho, Chen-Lung;
Hua, Kuo-Feng

Publication type:

Article

Emerging Immunotherapy Targets in Early Drug Development.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5394, doi. 10.3390/ijms26115394

By:

Morchón-Araujo, Daniel;
Catani, Greta;
Mirallas, Oriol;
Pretelli, Giulia;
Sánchez-Pérez, Vicky;
Vieito, María;
Braña, Irene;
Pujol-Borrell, Ricardo;
Garralda, Elena;
Hernando-Calvo, Alberto

Publication type:

Article

Metabolic Imaging of Hyperpolarized [1- 13 C]Pyruvate in a Ferret Model of Traumatic Brain Injury.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5327, doi. 10.3390/ijms26115327

By:

Mayer, Dirk;
Eldirdiri, Abubakr;
Hrdlick, Amanda L.;
Piskoun, Boris;
Rogers, Joshua C.;
Jhajharia, Aditya;
Zhu, Minjie;
Proctor, Julie L.;
Leiste, Ulrich H.;
Fourney, William L.;
Cantu, Jody C.;
Fiskum, Gary;
Goodfellow, Molly J.

Publication type:

Article

Virtual Screening of Novel Benzothiozinone Derivatives to Predict Potential Inhibitors of Mycobacterium Tuberculosis Kinases 2D-QSAR, Molecular Docking, MM-PBSA Dynamics Simulations, and ADMET Properties.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5129, doi. 10.3390/ijms26115129

By:

Guendouzi, Abdelmadjid;
Belkhiri, Lotfi;
Slimani, Zakaria;
Guendouzi, Abdelkrim;
Moroy, Gautier

Publication type:

Article

Synthesis, In Vitro Anti-Inflammatory Activity, Molecular Docking, Molecular Dynamics and DFT Calculations of Thiazoline-2-Thione Derivatives.

Published in:

Applied Sciences (2076-3417), 2025, v. 15, n. 11, p. 6095, doi. 10.3390/app15116095

By:

Farial, Bahaz;
Lotfi, Bourougaa;
Takoua, Belghit;
Sameh, Hadjar;
Zinelaabidine, Cheraiet;
Mandumpal, Jestin;
Abdelfattah, Mohamed A. O.;
Maroua, Fattouche;
Abdelkrim, Gouasmia

Publication type:

Article

Anticancer Effects of Withanolides: In Silico Prediction of Pharmacological Properties.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2457, doi. 10.3390/molecules30112457

By:

Silva, Gustavo Werneck de Souza e;
Marques, André Mesquita;
Sampaio, André Luiz Franco

Publication type:

Article

Bactericidal Effect of Synthetic Phenylalkylamides Inspired by Gibbilimbol B Against Neisseria gonorrhoeae.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2406, doi. 10.3390/molecules30112406

By:

Oliveira, Larissa V. F.;
Tempone, Andre G.;
Christodoulides, Myron;
Lago, Joao Henrique G.

Publication type:

Article

Gating Mechanism for Biased Agonism at Angiotensin II Type 1 Receptors.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2399, doi. 10.3390/molecules30112399

By:

Moore, Graham J.;
Ridgway, Harry;
Gadanec, Laura Kate;
Apostolopoulos, Vasso;
Zulli, Anthony;
Matsoukas, John M.

Publication type:

Article

Antimicrobial resistance and antimicrobial stewardship: an update.

Published in:

Wound Practice & Research, 2025, v. 33, n. 2, p. 79, doi. 10.33235/wpr.33.2.79-96

By:

Rippon, Mark G.;
Rogers, Alan A.;
Ousey, Karen

Publication type:

Article

SCATrans: semantic cross-attention transformer for drug–drug interaction predication through multimodal biomedical data.

Published in:

BMC Bioinformatics, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12859-025-06165-6

By:

Zhang, Shanwen;
Yu, Changqing;
Zhang, Chuanlei

Publication type:

Article

Wnt/β-catenin mediated signaling pathways in cancer: recent advances, and applications in cancer therapy.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02363-1

By:

Wu, Xiuzhu;
Que, Haiying;
Li, Qingfang;
Wei, Xiawei

Publication type:

Article

Brain injury biomarkers as targets for drugs development and personalized treatment for traumatic brain injury patients.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1606174

By:

Sandler, Melissa;
Almohaish, Sulaiman;
Brophy, Gretchen M.

Publication type:

Article

Optimization of automated patch-clamp technique and comparative analysis with manual patch-clamp: A case study on the TRPV1 channel.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2025, v. 34, n. 5, p. 485, doi. 10.5246/jcps.2025.05.037

By:

Guifang Duan;
Yue Li;
Xia Yuan;
Shuxiang Song;
Yingli Xu;
Jianchun Zhou

Publication type:

Article

Sample-size determination for decentralized clinical trials.

Published in:

International Journal of Epidemiology, 2025, v. 54, n. 3, p. 1, doi. 10.1093/ije/dyaf053

By:

Tian, Feng;
Lin, Ruitao;
Liu, Suyu;
Yuan, Ying

Publication type:

Article

Cost and Duration of Clinical Trials in Drug Development by Japanese Pharmaceutical Companies.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 3, p. 199, doi. 10.1007/s40290-025-00558-x

By:

Okada, Norihiro;
Takahashi, Yosuke

Publication type:

Article

Importance of Health Economics and Outcomes Research in the Product Lifecycle.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 3, p. 157, doi. 10.1007/s40290-025-00564-z

By:

Dang, Amit

Publication type:

Article

"Regression to the truth": lessons learned from negative IPF trials.

Published in:

Breathe, 2025, v. 21, n. 2, p. 1, doi. 10.1183/20734735.0260-2024

By:

Trachalaki, Athina;
Lindahl, Anna L.;
Petrarulo, Simone;
Margaritopoulos, George A.

Publication type:

Article

Structural Basis of Sequential Enantioselective Epoxidation by a Flavin‐Dependent Monooxygenase in Lasalocid A Biosynthesis.

Published in:

Angewandte Chemie, 2025, v. 137, n. 24, p. 1, doi. 10.1002/ange.202504982

By:

Wang, Qian;
Deng, Yaming;
Viera, Dayan;
Liu, Xiaopeng;
Liu, Ning;
Hu, Yulu;
Hu, Xiangdong;
Wei, Hao;
Zhou, Quan;
Lan, Ting;
He, Wei;
Chen, Xi;
Kim, Chu‐Young

Publication type:

Article

Pathogenicity analysis of a Chinese Genogroup II Akabane virus strain (TJ2016) in mouse models.

Published in:

Virology Journal, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12985-025-02819-2

By:

Wang, Jingjing;
Yu, Ruyang;
Wei, Fang;
Chen, Dongjie;
Wu, Shaoqiang

Publication type:

Article

抗体医薬品の現状と課題.

Published in:

Research on Drug Interactions, 2025, v. 49, n. 1, p. 2

By:

佐藤祥子

Publication type:

Article

B7–H3 and c-MET in advanced prostate cancer: exploring possibilities of novel bi-specific drug development.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02729-7

By:

He, Weiying;
Li, Huiyu;
Sun, Wenjia;
Zhang, Yanggeling;
Wu, De;
Ao, Chunxia;
Wang, Jincheng;
Yang, Yanan;
Xiao, Xuexue;
Zhang, Luyao;
Yue, Junqiu;
Wang, Xiyuan

Publication type:

Article

A Flexible Method Using a Parametric Bootstrap for Reducing Bias in Adaptive Designs With Treatment Selection.

Published in:

Statistics in Biopharmaceutical Research, 2014, v. 6, n. 2, p. 163, doi. 10.1080/19466315.2014.897251

By:

Pickard, Michael D.;
Chang, Mark

Publication type:

Article

A Quantitative Process for Enhancing End of Phase 2 Decisions.

Published in:

Statistics in Biopharmaceutical Research, 2014, v. 6, n. 1, p. 67, doi. 10.1080/19466315.2013.852617

By:

Sabin, Tony;
Matcham, James;
Bray, Sarah;
Copas, Andrew;
Parmar, Mahesh K. B.

Publication type:

Article

Contributions of Robert T. O'Neill to the Evolution of Regulatory Statistical Science.

Published in:

Statistics in Biopharmaceutical Research, 2013, v. 5, n. 3, p. 262, doi. 10.1080/19466315.2013.818817

By:

Anello, Charles;
Junod, Suzanne

Publication type:

Article

Statistical Issues and Controversies in Active-Controlled, "Noninferiority" Trials.

Published in:

Statistics in Biopharmaceutical Research, 2013, v. 5, n. 3, p. 229, doi. 10.1080/19466315.2013.786651

By:

Carroll, Kevin J.

Publication type:

Article

Being Efficient About Efficacy Estimation.

Published in:

Statistics in Biopharmaceutical Research, 2013, v. 5, n. 3, p. 204, doi. 10.1080/19466315.2012.754726

By:

Senn, Stephen

Publication type:

Article

Is It Time to Revisit the Role of Interleukin-1 Inhibitors in Osteoarthritis?

Published in:

Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2025, v. 18, p. 1753, doi. 10.2147/DMSO.S520465

By:

Brom, Martin;
Saxer, Franziska;
Mindeholm, Linda;
Schieker, Matthias;
Conaghan, Philip G

Publication type:

Article

Fullerenes in vivo. Toxicity and protective effects.

Published in:

Nanotoxicology, 2025, v. 19, n. 3, p. 233, doi. 10.1080/17435390.2025.2471273

By:

Bolshakova, Olga;
Zherebyatieva, Olga;
Sarantseva, Svetlana V.

Publication type:

Article

基于CRISPR-Cas系统的多重耐药菌防治技术研究进展.

Published in:

Biotechnology Bulletin, 2025, v. 41, n. 5, p. 42, doi. 10.13560/j.cnki.biotech.bull.1985.2024-0872

By:

周倩;
唐梦君;
张小燕;
陆俊贤;
唐修君;
杨星星;
高玉时

Publication type:

Article

Optimizing enzyme inhibition analysis: precise estimation with a single inhibitor concentration.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60468-z

By:

Jang, Hyeong Jun;
Song, Yun Min;
Jeon, Jang Su;
Yun, Hwi-yeol;
Kim, Sang Kyum;
Kim, Jae Kyoung

Publication type:

Article

A comprehensive antigen-antibody complex database unlocking insights into interaction interface.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104934

By:

Yuwei Zhou;
Wenwen Liu;
Ziru Huang;
Yushu Gou;
Siqi Liu;
Lixu Jiang;
Yue Yang;
Jian Huang

Publication type:

Article

Immunogenicity risk assessment for tailored mitigation and monitoring of biotherapeutics during development: recommendations from the European Immunogenicity Platform.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1581153

By:

Grudzinska-Goebel, Joanna;
Benstein, Karin;
Bloem, Karien;
Cowan, Kyra J.;
Gorovits, Boris;
Jadhav, Maria;
Janssen, Melody;
Jawa, Vibha;
Kiessling, Andrea;
Kramer, Daniel;
Kromminga, Arno;
van der Linden, Marcel;
Liu, Susana;
Lotz, Gregor P.;
Luo, Linlin;
Malisauskas, Mantas;
Marban-Doran, Céline;
Mytych, Daniel T.;
Oquendo Cifuentes, Elisa;
Pippig, Susanne

Publication type:

Article

Metabotropic glutamate receptors 2 and 3 as targets for treating schizophrenia.

Published in:

European Journal of Clinical & Experimental Medicine, 2025, v. 23, p. 67

By:

Niemiec, Hubert;
Zawodnik, Zuzanna;
Pańczyszyn-Trzewik, Patrycja;
Sowa-Kućma, Magdalena

Publication type:

Article

抗肿瘤药物Ⅰ期临床试验质量管理要点.

Published in:

Cancer Research on Prevention & Treatment, 2025, v. 52, n. 5, p. 347, doi. 10.3971/j.issn.1000-8578.2025.24.1178

By:

龚莉;
廖斌;
沈杰;
赵娟;
龚奕;
卢潇潇;
杨辉尧;
李沙;
李咏生

Publication type:

Article

In silico screening, ADMET analysis and computational simulation studies on Garcinia indica Choisy phytoconstituents as prospective antibreast cancer agents: a critical appraisal of the neglected plant.

Published in:

3 Biotech, 2025, v. 15, n. 7, p. 1, doi. 10.1007/s13205-025-04365-8

By:

Kushwaha, Pooja;
Mehrotra, Sudhir;
Ahmad, Rumana

Publication type:

Article

AI in fungal drug development: opportunities, challenges, and future outlook.

Published in:

Frontiers in Cellular & Infection Microbiology, 2025, p. 1, doi. 10.3389/fcimb.2025.1610743

By:

Li, Yanjian;
Qiao, Yue;
Ma, Yuanyuan;
Xue, Peng;
Ding, Chen

Publication type:

Article

Living With Sjögren Disease: Prospects for Disease‐Modifying Therapies.

Published in:

Arthritis & Rheumatology, 2025, v. 77, n. 5, p. 499, doi. 10.1002/art.43060

By:

St. Clair, E. William

Publication type:

Article

New discoveries in therapeutic targets and drug development pathways for type 2 diabetes mellitus under the guidance of precision medicine.

Published in:

European Journal of Medical Research, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s40001-025-02682-5

By:

Tian, Xinyi;
Wang, Liuqing;
Zhang, Lu;
Chen, Xiao;
Wang, Wenjun;
Zhang, Kaiqi;
Ge, Xiaolei;
Luo, Zhengrong;
Zhai, Xu;
Shao, Huaqiang

Publication type:

Article

Supplementary approaches to perinatal depression: a review of pathogenesis, herbal interventions, and dietary supplements.

Published in:

Frontiers in Psychology, 2025, p. 1, doi. 10.3389/fpsyg.2025.1529339

By:

Yang, Quancheng;
Lv, Yi;
Gao, Shenrong;
Zhang, Yu;
Zhai, Xuejia

Publication type:

Article

The Emerging Landscape of Tubercular Targets: A Medicinal Chemistry Approach.

Published in:

Medicinal Research Reviews, 2025, v. 45, n. 4, p. 1077, doi. 10.1002/med.22100

By:

Shaik, Baji Baba;
Moodley, Kimeshni;
Ghumran, Safiyah;
Bala, Muhammad D.;
Singh, Parvesh;
Karpoormath, Rajshekhar

Publication type:

Article

Investigation of Degradation Behavior of Antimycotic Imidazoles under Stress Conditions and Quantification in Commercial Products.

Published in:

Pharmaceutical Chemistry Journal, 2025, v. 59, n. 1, p. 111, doi. 10.1007/s11094-025-03370-8

By:

ÜSTÜN, Zehra

Publication type:

Article