Works matching DE "MTOR inhibitors"

Results: 728

mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104979

By:

Stavrides, Philip;
Goulbourne, Chris N.;
Peddy, James;
Chunfeng Huo;
Mala Rao;
Khetarpal, Vinod;
Marchionini, Deanna M.;
Nixon, Ralph A.;
Dun-Sheng Yang

Publication type:

Article

Transplacental sirolimus: a new treatment strategy for life-threatening fetal cardiac rhabdomyomas—a case report.

Published in:

2025

By:

Uno, Kaname;
Nomura, Yoji;
Kawaguchi, Masahiro;
Ebina, Anna;
Imanishi, Rina;
Kawai, Satoru;
Hayakawa, Hiromi

Publication type:

Letter

The increase in autophagy induced by naringin alleviates Schwann cell apoptosis mediated by the AMPK/mTOR signalling pathway.

Published in:

Journal of Orthopaedic Surgery & Research, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13018-025-05969-9

By:

Lv, Jianwei;
Shan, Duo;
Jia, Haobo;
Wang, Zengliang

Publication type:

Article

A Phase I/II Trial of Sapanisertib in Advanced Anaplastic and Radioiodine Refractory Differentiated Thyroid Carcinoma.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2025, v. 110, n. 5, p. 1315, doi. 10.1210/clinem/dgae443

By:

Sehgal, Kartik;
Serritella, Anthony;
Liu, Mofei;
ONeill, Anne;
Nangia, Chaitali;
Pappa, Theodora;
Demeure, Michael J;
Worden, Francis P;
Haddad, Robert I;
Lorch, Jochen

Publication type:

Article

Chondrosarcoma: Multi-Targeting Therapeutic Effects of Doxorubicin, BEZ235, and the Small Molecule Aspartyl-Asparaginyl-β-hydroxylase Inhibitor SMI1182.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1671, doi. 10.3390/cancers17101671

By:

Fife, Megan;
Tong, Ming;
Das, Bhaskar;
Rodriguez, Rene;
Chokkalingam, Parthiban;
Carlson, Rolf I.;
de la Monte, Suzanne M.

Publication type:

Article

PI3Kδ as a Novel Therapeutic Target for Aggressive Prostate Cancer.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1610, doi. 10.3390/cancers17101610

By:

Wang, Bi-Dar;
Lucero, Alyssa;
Ha, Siyoung;
Yarmohammadi, Reyhaneh

Publication type:

Article

mTOR inhibitor sirolimus negatively impacts in vitro fertilization outcomes.

Published in:

Journal of Assisted Reproduction & Genetics, 2019, v. 36, n. 5, p. 947, doi. 10.1007/s10815-019-01439-4

By:

Wald, Kaitlyn;
Cakmak, Hakan;
Noel, Martha

Publication type:

Article

Hesperetin regulates PI3K/Akt and mTOR pathways to exhibit its antiproliferative effect against colon cancer cells.

Published in:

Biotechnic & Histochemistry, 2024, v. 99, n. 6, p. 287, doi. 10.1080/10520295.2024.2382764

By:

Saiprasad, Gowrikumar;
Chitra, Palanivel;
Manikandan, Ramar;
Koodalingam, Arunagirinathan;
Sudhandiran, Ganaspasam

Publication type:

Article

Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.

Published in:

BioMetals, 2017, v. 30, n. 6, p. 975, doi. 10.1007/s10534-017-0059-1

By:

Huang, Hui;
Chen, Jun;
Lu, Huiru;
Zhou, Mengxue;
Chai, Zhifang;
Hu, Yi

Publication type:

Article

Quantitative evaluation of the efficacy and safety profiles of two types of targeted inhibitors combined with endocrine therapy in ER+/HER2− metastatic breast cancer.

Published in:

European Journal of Clinical Pharmacology, 2024, v. 80, n. 9, p. 1387, doi. 10.1007/s00228-024-03715-4

By:

Pan, Meiyu;
Lin, Yan;
Liu, Yinhui;
Xu, Ruijuan;
Yang, Jin

Publication type:

Article

Short- and long-term effects of leucine and branched-chain amino acid supplementation of a protein- and energy-reduced diet on muscle protein metabolism in neonatal pigs.

Published in:

Amino Acids, 2018, v. 50, n. 7, p. 943, doi. 10.1007/s00726-018-2572-0

By:

Manjarín, Rodrigo;
Columbus, Daniel A.;
Solis, Jessica;
Hernandez-García, Adriana D.;
Suryawan, Agus;
Nguyen, Hanh V.;
McGuckin, Molly M.;
Jimenez, Rafael T.;
Fiorotto, Marta L.;
Davis, Teresa A.

Publication type:

Article

GPR43 Suppresses Intestinal Tumor Growth by Modification of the Mammalian Target of Rapamycin Complex 1 Activity in ApcMin/+ Mice.

Published in:

2022

By:

Kong, Lingling;
Hoshi, Namiko;
Sui, Yunlong;
Yamada, Yasutaka;
Yoshida, Ryutaro;
Ooi, Makoto;
Tian, Zibin;
Kimura, Ikuo;
Kodama, Yuzo

Publication type:

journal article

Indication for a Pneumocystis Prophylaxis Therapy in Patients with Vascular Anomalies Treated with PIK3/AKT/mTOR Pathway Inhibitors: Experts' Opinion and Systematic Review from the Literature.

Published in:

Dermatology (10188665), 2023, v. 239, n. 6, p. 942, doi. 10.1159/000533675

By:

Navarro, Maxime;
Allemang-Trivalle, Aude;
Leducq, Sophie;
Jonville-Bera, Annie-Pierre;
Maurier, Anaïs;
Zejli, Tarik;
Edée, Afi-Emiliène;
Harchaoui, Emilie;
Giraudeau, Bruno;
Maruani, Annabel

Publication type:

Article

Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors.

Published in:

Biochemical Journal, 2020, v. 477, n. 10, p. 1847, doi. 10.1042/BCJ20190958

By:

Melick, Chase H.;
Jewell, Jenna L.

Publication type:

Article

Cytotoxic and Cytostatic Effects of Targeting mTOR and Hedgehog Pathways in Acute Myeloid Leukemia.

Published in:

Experimed, 2022, v. 12, n. 3, p. 202, doi. 10.26650/experimed.1193721

By:

Cicek, Enes;
Kucuktas, Fulya Mina;
Yenigul, Munevver;
Gencer Akcok, Emel Basak

Publication type:

Article

Racial Differences in ctDNA Profiles, Targeted Therapy Use, and Outcomes in Metastatic Breast Cancer.

Published in:

JAMA Network Open, 2025, v. 8, n. 2, p. e2461899, doi. 10.1001/jamanetworkopen.2024.61899

By:

Podany, Emily L.;
Foffano, Lorenzo;
Gerratana, Lorenzo;
Medford, Arielle J.;
Clifton, Katherine;
Tapiavala, Shaili;
Velimirovic, Marko;
Lipsyc-Sharf, Marla;
Reduzzi, Carolina;
Bubie, Adrian;
Putur, Annika;
Ademuyiwa, Foluso O.;
Puglisi, Fabio;
Gradishar, William J.;
Ma, Cynthia X.;
Bardia, Aditya;
Cristofanilli, Massimo;
Davis, Andrew A.

Publication type:

Article

Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 3, p. 1, doi. 10.1080/23723556.2021.1902250

By:

Rathore, Richa;
Van Tine, Brian

Publication type:

Article

Targeting ganglioneuromas with mTOR inhibitors.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 1, p. 1, doi. 10.1080/23723556.2020.1856621

By:

Tao, Ting;
Shi, Hui;
Durbin, Adam D.;
Look, A. Thomas

Publication type:

Article

Phosphatidic acid: a lipid regulator of the Hippo pathway.

Published in:

Molecular & Cellular Oncology, 2019, v. 6, n. 1, p. 1, doi. 10.1080/23723556.2018.1558683

By:

Han, Han;
Vargas, Rebecca;
Seo, Gayoung;
Wang, Wenqi

Publication type:

Article

The role of mTOR signaling pathway in premalignant and malignant cervical lesions.

Published in:

European Journal of Gynaecological Oncology, 2015, v. 36, n. 1, p. 36, doi. 10.12892/ejgo2563.2015

By:

Andrikopoulou, M.;
Salakos, N.;
Deligeoroglou, E.;
Pafiti, A.;
Boutas, I.;
Nikitakis, N.;
Sklavounou, A.;
Creatsas, G.

Publication type:

Article

Seizure reduction in TSC2‐mutant mouse model by an mTOR catalytic inhibitor.

Published in:

Annals of Clinical & Translational Neurology, 2023, v. 10, n. 10, p. 1790, doi. 10.1002/acn3.51868

By:

Dhamne, Sameer C.;
Modi, Meera E.;
Gray, Audrey;
Bonazzi, Simone;
Craig, Lucas;
Bainbridge, Elizabeth;
Lalani, Lahin;
Super, Chloe E.;
Schaeffer, Samantha;
Capre, Ketthsy;
Lubicka, Danuta;
Liang, Guiqing;
Burdette, Doug;
McTighe, Stephanie M.;
Gurnani, Sarika;
Vermudez, Sheryl Anne D.;
Curtis, Daniel;
Wilson, Christopher J.;
Hameed, Mustafa Q.;
D'Amore, Angelica

Publication type:

Article

Sirolimus for epileptic seizures associated with focal cortical dysplasia type II.

Published in:

Annals of Clinical & Translational Neurology, 2022, v. 9, n. 2, p. 181, doi. 10.1002/acn3.51505

By:

Kato, Mitsuhiro;
Kada, Akiko;
Shiraishi, Hideaki;
Tohyama, Jun;
Nakagawa, Eiji;
Takahashi, Yukitoshi;
Akiyama, Tomoyuki;
Kakita, Akiyoshi;
Miyake, Noriko;
Fujita, Atsushi;
Saito, Akiko M.;
Inoue, Yushi

Publication type:

Article

Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report.

Published in:

Oncology Letters, 2023, v. 25, n. 5, p. N.PAG, doi. 10.3892/ol.2023.13780

By:

Lygina, Elena;
Morgacheva, Daria;
Khadela, Avinash;
Postwala, Humzah;
Shah, Yesha;
Dinikina, Yulia

Publication type:

Article

CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1-mediated Warburg effect.

Published in:

Oncology Letters, 2022, v. 23, n. 2, p. N.PAG, doi. 10.3892/ol.2022.13190

By:

Yang, Wenyu;
Wang, Yanchun;
Tao, Chunhui;
Li, Yunhai;
Cao, Shan;
Yang, Xiqian

Publication type:

Article

Synergistic antitumor effect of dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with cisplatin on drug-resistant non-small cell lung cancer cell.

Published in:

Oncology Letters, 2020, v. 20, n. 6, p. N.PAG, doi. 10.3892/ol.2020.12189

By:

Zhu, Hao;
Shi, Yuhuan;
Jiao, Xiuxiu;
Yang, Gang;
Wang, Rong;
Yuan, Yongfang

Publication type:

Article

Combining the mammalian target of rapamycin inhibitor, rapamycin, with resveratrol has a synergistic effect in multiple myeloma.

Published in:

Oncology Letters, 2018, v. 15, n. 5, p. 6257, doi. 10.3892/ol.2018.8178

By:

Jin, Hong-Guang;
Wu, Guo-Zhen;
Wu, Guo-Hua;
Bao, Yong-Ge

Publication type:

Article

Effect and molecular mechanism of mTOR inhibitor rapamycin on temozolomide-induced autophagic death of U251 glioma cells.

Published in:

Oncology Letters, 2018, v. 15, n. 2, p. 2477, doi. 10.3892/ol.2017.7537

By:

Li, Bing;
Zhou, Chun;
Yi, Liang;
Xu, Lunshan;
Xu, Minhui

Publication type:

Article

Tuberous Sclerosis Complex: New Insights into Pathogenesis and Therapeutic Breakthroughs.

Published in:

Life (2075-1729), 2025, v. 15, n. 3, p. 368, doi. 10.3390/life15030368

By:

Jurca, Aurora Alexandra;
Jurca, Alexandru Daniel;
Petchesi, Codruta Diana;
Bembea, Dan;
Jurca, Claudia Maria;
Severin, Emilia;
Jurca, Sanziana;
Vesa, Cosmin Mihai

Publication type:

Article

CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.580407

By:

Guo, Yangyang;
Zhu, Hengyue;
Weng, Min;
Zhang, Hewei;
Wang, Cheng;
Sun, Linxiao

Publication type:

Article

Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01285

By:

Torp, May-Kristin;
Yang, Kuan;
Ranheim, Trine;
Husø Lauritzen, Knut;
Alfsnes, Katrine;
Vinge, Leif E.;
Aukrust, Pål;
Stensløkken, Kåre-Olav;
Yndestad, Arne;
Sandanger, Øystein

Publication type:

Article

Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00051

By:

Hosseinzade, Aysooda;
Sadeghi, Omid;
Naghdipour Biregani, Akram;
Soukhtehzari, Sepideh;
Brandt, Gabriel S.;
Esmaillzadeh, Ahmad

Publication type:

Article

Regulation of Dendritic Cell Immune Function and Metabolism by Cellular Nutrient Sensor Mammalian Target of Rapamycin (mTOR).

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2018.03145

By:

Snyder, Julia P.;
Amiel, Eyal

Publication type:

Article

Mechanistic target of rapamycin inhibition with rapamycin induces autophagy and correlative regulation in white shrimp (Litopenaeus vannamei).

Published in:

Aquaculture Nutrition, 2018, v. 24, n. 5, p. 1509, doi. 10.1111/anu.12688

By:

Liu, Xinwei;
Wang, Mengqiang;
Sun, Guoqiong;
Wang, Baojie;
Jiang, Keyong;
Shao, Jianchun;
Qi, Cancan;
Zhao, Wei;
Han, Siyin;
Liu, Mei;
Wang, Lei

Publication type:

Article

Immunosuppression in Simultaneous Pancreas-kidney Transplantation.

Published in:

2023

By:

Roozbeh, Jamshid

Publication type:

Abstract

mTOR Inhibitors in Pediatric Liver Transplantation.

Published in:

International Journal of Organ Transplantation Medicine, 2023, v. 14, n. 4, p. 65

By:

Moghadamnia, Marjan

Publication type:

Article

Is Early Conversion to mTOR Inhibitors Represent a Suitable Choice in Renal Transplant Recipients? A Systemic Review of Medium-term Outcomes.

Published in:

International Journal of Organ Transplantation Medicine, 2017, v. 8, n. 2, p. 68

By:

Kumar, J.;
Reccia, I.;
Kusano, T.

Publication type:

Article

Primitive Cutaneous (P)erivascular (E)pithelioid (C)ell Tumour (PEComa): A New Case Report of a Rare Cutaneous Tumor.

Published in:

Genes, 2022, v. 13, n. 7, p. 1153, doi. 10.3390/genes13071153

By:

Cazzato, Gerardo;
Colagrande, Anna;
Lospalluti, Lucia;
Pacello, Lucia;
Lettini, Teresa;
Arezzo, Francesca;
Loizzi, Vera;
Lupo, Carmelo;
Casatta, Nadia;
Cormio, Gennaro;
Maiorano, Eugenio;
Ingravallo, Giuseppe;
Resta, Leonardo

Publication type:

Article

Development of Tat-fused drug binding protein to improve anti-cancer effect of mammalian target of rapamycin inhibitors.

Published in:

Biotechnology & Bioprocess Engineering, 2024, v. 29, n. 2, p. 303, doi. 10.1007/s12257-024-00015-7

By:

Lim, Su Yeon;
Kim, Sugyeong;
Kim, Hongbin;
Kim, Hyun-Ouk;
Ha, Suk-Jin;
Lim, Kwang Suk

Publication type:

Article

Lymphatic Malformation Responsive to Sirolimus in Keratinocytic Epidermal Nevus Syndrome with KRAS Mutation: A Case and Brief Literature Discussion.

Published in:

Case Reports in Dermatology, 2021, v. 13, n. 1, p. 195, doi. 10.1159/000515247

By:

Sideris, Emily;
Tng, Er Tsing Vivian;
Chee, Paul

Publication type:

Article

Taraxacum Mongolicum Polysaccharides Reverses Mice Obesity via Activation of AKT/mTOR Pathway.

Published in:

Nutrients, 2024, v. 16, n. 19, p. 3330, doi. 10.3390/nu16193330

By:

Yue, Xiaoyu;
Yu, Shilong;
Luan, Yue;
Wang, Jianpeng;
Zhao, Junxing;
Zhang, Mu;
Wang, Qin

Publication type:

Article

Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity.

Published in:

Nutrients, 2024, v. 16, n. 15, p. 2509, doi. 10.3390/nu16152509

By:

Bartkowiak-Wieczorek, Joanna;
Malesza, Michał;
Malesza, Ida;
Hadada, Tomasz;
Winkler-Galicki, Jakub;
Grzelak, Teresa;
Mądry, Edyta

Publication type:

Article

Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models.

Published in:

Nutrients, 2024, v. 16, n. 14, p. 2369, doi. 10.3390/nu16142369

By:

Márquez-Garbán, Diana C.;
Yanes, Cristian D.;
Llarena, Gabriela;
Elashoff, David;
Hamilton, Nalo;
Hardy, Mary;
Wadehra, Madhuri;
McCloskey, Susan A.;
Pietras, Richard J.

Publication type:

Article

Duality of Branched-Chain Amino Acids in Chronic Cardiovascular Disease: Potential Biomarkers versus Active Pathophysiological Promoters.

Published in:

Nutrients, 2024, v. 16, n. 12, p. 1972, doi. 10.3390/nu16121972

By:

Tanase, Daniela Maria;
Valasciuc, Emilia;
Costea, Claudia Florida;
Scripcariu, Dragos Viorel;
Ouatu, Anca;
Hurjui, Loredana Liliana;
Tarniceriu, Claudia Cristina;
Floria, Diana Elena;
Ciocoiu, Manuela;
Baroi, Livia Genoveva;
Floria, Mariana

Publication type:

Article

Hepatic-Metabolic Activity of α-Lipoic Acid—Its Influence on Sphingolipid Metabolism and PI3K/Akt/mTOR Pathway in a Rat Model of Metabolic Dysfunction-Associated Steatotic Liver Disease.

Published in:

Nutrients, 2024, v. 16, n. 10, p. 1501, doi. 10.3390/nu16101501

By:

Sztolsztener, Klaudia;
Chabowski, Adrian

Publication type:

Article

Tyrosine Is a Booster of Leucine-Induced Muscle Anabolic Response.

Published in:

Nutrients, 2024, v. 16, n. 1, p. 84, doi. 10.3390/nu16010084

By:

Tamura, Kotaro;
Kitazawa, Hidefumi;
Sugita, Satoshi;
Hashizume, Kohjiro;
Iwashita, Masazumi;
Ishigami, Takaaki;
Minegishi, Yoshihiko;
Shimotoyodome, Akira;
Ota, Noriyasu

Publication type:

Article

Anti-Inflammatory Mechanisms of Curcumin and Its Metabolites in White Adipose Tissue and Cultured Adipocytes.

Published in:

Nutrients, 2024, v. 16, n. 1, p. 70, doi. 10.3390/nu16010070

By:

Islam, Tariful;
Scoggin, Shane;
Gong, Xiaoxia;
Zabet-Moghaddam, Masoud;
Kalupahana, Nishan S.;
Moustaid-Moussa, Naima

Publication type:

Article

Effective Disease Control After Combinatorial Treatment with a PD-1 Antibody and an mTOR Inhibitor for Recurrent Ovarian Clear Cell Carcinomas: A Case Report and Literature Review.

Published in:

OncoTargets & Therapy, 2021, v. 14, p. 5429, doi. 10.2147/OTT.S333029

By:

Li, Yue;
Liu, wentao;
Yue, Xiaolong;
Fang, Yu;
Zhang, Xiaoyan;
Zhang, Xin;
He, Qifan;
Fu, Na;
Wang, Sizhen;
Ma, Tonghui;
Li, Dalin

Publication type:

Article

AG-1024 Sensitizes Sorafenib-Resistant Hepatocellular Carcinoma Cells to Sorafenib via Enhancing G1/S Arrest.

Published in:

OncoTargets & Therapy, 2021, v. 14, p. 1049, doi. 10.2147/OTT.S289324

By:

Zhou, Wei;
Lou, Weiyang;
Chen, Junru;
Ding, Bisha;
Chen, Binjie;
Xie, Haiyang;
Zhou, Lin;
Zheng, Shusen;
Jiang, Donghai

Publication type:

Article

Novel mTOR Inhibitor Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeting Agents.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 7165, doi. 10.2147/OTT.S244474

By:

Feng, Ying-Qi;
Li, Bo-An;
Feng, Fan;
Chen, Yong-Shou;
Ren, Yi-Xin;
Zhang, Heng;
Cao, Shuang

Publication type:

Article

Inhibition of esophageal cancer growth through the suppression of PI3K/AKT/mTOR signaling pathway.

Published in:

OncoTargets & Therapy, 2019, v. 12, p. 7637, doi. 10.2147/OTT.S205457

By:

Shi, Ni;
Yu, Hao;
Chen, Tong

Publication type:

Article