Results
Title

Wound Healing Effect of Lawsonia inermis.

Authors

Rekik, Dorsaf Moalla; Ben Khedir, Sameh; Daoud, Amal; Ksouda Moalla, Kamilia; Rebai, Tarak; Sahnoun, Zouheir

Abstract

Background:Lawsonia inermis-extracted oil is known for therapeutic properties, especially wound healing. This study assesses the potential of this oil for wound healing in a rat model. Methodology: To assess the potential of L. inermis-extracted oil for wound healing, phytochemical, antibacterial, and antioxidant analyses were conducted. Uniform wound excision was induced on the dorsum of randomly selected rats divided into 3 groups cleaned and treated with saline solution (control), Cicaflora (reference), and L. inermisoil. Biopsies performed after healing were histologically assessed. Conclusions: The quality and content of the fatty acids in the oil were determined. Results showed a high content of bioactive components inducing an efficient wound healing effect determined by an in vivo study. Histological and chromatic assessment findings revealed healing in the oil-treated group but not in the untreated group, a full reepithelialization with reappearance of skin appendages and well-organized collagen fibers without any inflammatory cells. This might be due to a synergistic effect of the phytoconstituents present in the oil.

Subjects

HENNA (Plant); ESSENTIAL oils; WOUND healing; COLLAGEN; ANTIOXIDANTS

Publication

Skin Pharmacology & Physiology, 2019, Vol 32, Issue 6, p295

ISSN

1660-5527

Publication type

Academic Journal

DOI

10.1159/000501730