Background: Diabetes is associated with increasing prevalence of chronic kidney disease (CKD) and progression of the disease. Therefore, the objective of this study was to estimate the prevalence of diabetes among patients with CKD in the Hail region, Kingdom of Saudi Arabia. Methods: This is a cross-sectional study carried in the nephrology outpatients' clinic at King Khalid Hospital. A total of 200 patients known to have CKD were included in the study. Results: Ninety eight (49%) females and 102 (51%) males. The mean studied population age was 55.6 years, and females age was significantly lower than the males (P = 0.05). The overall prevalence of diabetes in patients with CKD was 69%, among them 73.9% had retinopathy. Diabetes and female gender were associated with more advanced stage of CKD (P value <0.05), mean average eGFR was significantly lower in patients with diabetes, (P = 0.05), eGFR correlated inversely with HbA1c (P = 0.05). The mean time of onset of CKD in diabetic patients after diagnosis of diabetes was 11.7 ± 0.67 years (p value <0.05). The association of diabetes and hypertension in patients with CKD; 87.7% were hypertensive and 72.6% of these patients were also diabetic (P = 0.05). Conclusion: The role of diabetes as a risk factor for CKD and ESRD is higher than it has been estimated in previous studies in Saudi Arabia. Females are at higher risk of CKD and eventually ESRD than males.