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Title: DCP-LA Exerts an Antiaging Action on the Skin.
Authors: Nishizaki, Tomoyuki
Abstract: The present study assessed the possibility for the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]- octanoic acid (DCP-LA) as an antiaging compound for the skin by assaying senescence-associated β-galactosidase (SA- β-Gal), a biomarker of senescence and cell viability. The nitric oxide (NO) donor sodium nitroprusside (SNP) increased in SA-β-Gal-positive cells in cultured human fibroblasts and mouse keratinocytes, and DCP-LA significantly inhibited the effect of SNP. Moreover, SNP induced cell death in cultured mouse keratinocytes, and DCP-LA significantly prevented NO stress-induced death of keratinocytes. Taken together, these results indicate that DCP-LA exerts an antiaging action on the skin.
Subjects: SKIN physiology; LINOLEIC acid; OCTANOIC acid; CELLULAR aging; CELL survival; SODIUM nitroferricyanide; KERATINOCYTES; THERAPEUTICS
Publication: Skin Pharmacology & Physiology, 2016, Vol 29, Issue 3, p157
ISSN: 1660-5527
Publication type: Academic Journal
DOI: 10.1159/000446216

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DCP-LA Exerts an Antiaging Action on the Skin.