We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Non-Sentinel Lymph Node Status and Prognosis of Breast Cancer Patients with Micrometastatic Sentinel Lymph Nodes.
- Authors
Onishi, T.; Jinno, H.; Takahashi, M.; Hayashida, T.; Sakata, M.; Nakahara, T.; Shigematsu, N.; Mukai, M.; Kitagawa, Y.
- Abstract
Background: The prognostic significance of sentinel lymph node (SLN) micrometastases and the need for axillary lymph node dissection (ALND) on patients with micrometastases in SLNs remain controversial. Methods: A prospective database of 657 breast cancer patients who underwent SLN biopsy (SLNB) was analyzed. SLNs were detected using a combined method of isosulfan blue dye and small-sized technetium-99m-labeled tin colloid. Results: Micrometastases in SLNs were found in 50 (7.6%) of 657 patients. Twenty-nine (58.0%) of 50 patients with micrometastatic SLNs underwent ALND and no further metastases were found in non-sentinel lymph nodes. Among 21 patients (42.0%) with micrometastatic SLNs who decided to forego ALND, no axillary lymph node recurrence has been observed during a median follow-up time of 47 months. There is no significant difference in recurrence-free survival between the patients with micrometastatic and negative SLNs (p = 0.90). Conclusions: These data suggest that it may not be necessary to perform ALND on patients with micrometastases in SLNs and that the presence of micrometastases in SLNs may not be associated with prognosis. Copyright © 2010 S. Karger AG, Basel
- Subjects
BREAST cancer diagnosis; LYMPH nodes; CANCER patients; S. Karger AG; CLINICAL pathology; COLLOIDS
- Publication
European Surgical Research, 2010, Vol 45, Issue 3/4, p344
- ISSN
0014-312X
- Publication type
Academic Journal
- DOI
10.1159/000321709