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Title

Effects of Paricalcitol and Enalapril on Atherosclerotic Injury in Mouse Aortas.

Authors

Husain, Kazim; Suarez, Edu; Isidro, Angel; Ferder, Leon

Abstract

Aims: This study investigated the protective effect of vitamin D analog paricalcitol combined with angiotensin-converting enzyme inhibitor (enalapril) on aortic oxidative injury in atherosclerotic mice. Methods: Female mice were treated for 16 weeks as follows: (1) ApoE deficient vehicle, (2) ApoE deficient paricalcitol (200 ng 3 times a week), (3) ApoE deficient enalapril (30 mg/l in drinking water), (4) ApoE deficient paricalcitol enalapril, and (5) wild-type controls. Results: ApoE-deficient mice developed hypertension which was prevented by enalapril or enalapril paricalcitol treatment but not by paricalcitol treatment. Histology showed atherosclerotic plaque in the aorta of ApoE-deficient mice which was prevented by paricalcitol, enalapril, and paricalcitol enalapril treatments. Aortic malondialdehyde levels, NADPH oxidase subunit p22phox, manganese-superoxide dismutase (Mn-SOD), inducible nitric oxide synthase, monocyte chemoattaractant protein-1, tumor necrosis factor (TNF)-α, and cyclooxygenase-2 protein expressions increased, whereas glutathione levels, CuZn-SOD, and endothelial protein expressions decreased in ApoE-deficient mice compared to controls. Treatment with paricalcitol and enalapril alone or in combination protected the inflammatory and oxidative endothelial injury of the aorta in atherosclerotic mice. Conclusion: Combination therapy affords greater protection against aortic inflammatory and oxidative injury in atherosclerosis than monotherapy. Copyright © 2010 S. Karger AG, Basel

Publication

American Journal of Nephrology, 2010, Vol 32, Issue 4, p296

ISSN

0250-8095

Publication type

Academic Journal

DOI

10.1159/000319445

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