Effect of Individualized Exercise Training Combined with Diet Restriction on Inflammatory Markers and IGF-1/IGFBP-3 in Obese Children.

Ounis, Omar Ben; Elloumi, Mohamed; Zouhal, Hassane; Makni, Emna; Denguezli, Myriam; Amri, Mohamed; Lac, Gérard; Tabka, Zouhair

Aims: The present study was designed to examine the possible changes in body composition, insulin-like growth factor 1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and inflammatory markers of obese children in response to a 2-month program of exercise training combined with dietary restriction. Methods: Twenty-eight obese children (age 13.2 ± 0.7 years, body mass index 30.9 ± 1.3) were randomly assigned to a diet/training group or a control group and were tested two times: once before and once at the end of the experimental period. They performed a progressive cycle ergometer test at each visit. Substrate oxidation was evaluated by indirect calorimetry. Training was individualized at the point when fat oxidation was maximal (Lipoxmax). Results: Diet/training induced a significant decrease in body weight and body fat (after vs. before, p 2maxACSM (24.6 ± 2.5 to 33.1 ± 3.1 ml/min/kg, p < 0.001) at the end of the intervention period. Conclu- sion: These data suggest that in the presence of weight loss, exercise training improves inflammatory markers and IGF-1 and IGFBP-3 levels in obese children. Copyright © 2010 S. Karger AG, Basel

INSULIN-like growth factor-binding proteins; SOMATOMEDIN; OVERWEIGHT children; CHILDHOOD obesity; CHILDREN'S health

Annals of Nutrition & Metabolism, 2010, Vol 56, Issue 4, p260

0250-6807

Academic Journal

10.1159/000275888