Responses of Monkeys with Pollinosis to Two Major Allergens of Japanese Cedar Pollen.

Hashimoto, M.; Kobayashi, T.; Nigi, H.; Saito, S.; Nakayama, I.; Narita, T.; Iwata, M.; Yasueda, H.; Taniguchi, Y.; Kurimoto, M.; Inouye, S.; Sakaguchi, M.

We examined the responses of two Japanese monkeys with pollinosis to two major allergens (Cry j 1 and Cry j 2) of Japanese cedar pollen. The two monkeys (A and B) had specific IgE antibodies to the allergens and showed a strong positive reaction to both of them in the intradermal test. In the histamine release test with peripheral blood mononuclear cells (PBMC), monkey A showed a typical pattern similar to that seen in human patients, while monkey B released a low level of histamine. The proliferative response of PBMC to both allergens in monkey A was weak, but was typical in monkey B. From clinical as well as immunological points of view, these monkeys may be a suitable animal model for Japanese cedar pollinosis in humans. Copyright © 1997 S. Karger AG, Basel

International Archives of Allergy & Immunology, 1997, Vol 112, Issue 1, p88

1018-2438

Academic Journal

10.1159/000237436