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Title

Mechanism of the Eosinophilic Differentiation of HL-60 Clone 15 Cells Induced by n-Butyrate.

Authors

Ishihara, Kenji; Hong, JangJa; Zee, OkPyo; Ohuchi, Kazuo

Abstract

n-Butyrate is one of the most powerful chemical inducers of the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into mature eosinophils. We have recently reported that the mechanism by which HL-60 clone 15 cells differentiate into eosinophils by n-butyrate is that n-butyrate continuously inhibits histone deacetylase activity as a histone deacetylase inhibitor, resulting in continuous acetylation of histones. In this review, we discuss roles of histone acetyltransferase, histone deacetylase and histone deacetylase inhibitors in the differentiation of HL-60 clone 15 cells into eosinophils. Copyright © 2005 S. Karger AG, Basel

Subjects

LEUKEMIA; EOSINOPHILS; GRANULOCYTES; HISTONES; LEUKOCYTES; CANCER

Publication

International Archives of Allergy & Immunology, 2005, Vol 137, p77

ISSN

1018-2438

Publication type

Academic Journal

DOI

10.1159/000085436