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- Title
Metoclopramide and Cellular Immune Functions during Polymicrobial Sepsis.
- Authors
Oberbeck, R.; Schmitz, D.; Wilsenack, K.; Pehle, B.; Schedlowski, M.; Schüler, M.; Exton, M. S.
- Abstract
Metoclopramide (MCP) has been demonstrated to restore the depressed cellular immune function after hemorrhage by increasing the release of the immunomodulatory pituitary hormone prolactin. We investigated the effect of MCP on serum prolactin concentrations, on cellular immune functions (immune cell distribution, splenocyte proliferation, apoptosis and cytokine release) and on the survival 48 h after induction of a polymicrobial sepsis in mice. Administration of MCP increased circulating serum prolactin concentrations and splenocyte apoptosis rate and improved cellular cytokine release, but did not affect mortality of septic mice. We therefore conclude that administration of MCP modulated splenocyte apoptosis and cytokine release in a murine model of sepsis without an impact on the survival. Furthermore, this effect may be mediated by an increased endogenous prolactin release. Copyright © 2004 S. Karger AG, Basel
- Subjects
SEPTICEMIA treatment; NAUSEA treatment; PROLACTIN; COMMUNICABLE diseases; APOPTOSIS
- Publication
European Surgical Research, 2004, Vol 36, Issue 2, p116
- ISSN
0014-312X
- Publication type
Academic Journal
- DOI
10.1159/000076652