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- Title
Assessment of Neuroinflammation and Microglial Activation in Alzheimer’s Disease with Radiolabelled PK11195 and Single Photon Emission Computed Tomography.
- Authors
Versijpt, Jan J.; Dumont, Filip; Van Laere, Koen J.; Decoo, Danny; Santens, Patrick; Audenaert, Kurt; Achten, Eric; Slegers, Guido; Dierckx, Rudi A.; Korf, Jakob
- Abstract
Objectives: Inflammation contributes to degeneration in Alzheimer’s disease (AD), not simply as a secondary phenomenon, but primarily as a significant source of pathology. [[sup 123] I]iodo-PK11195 is a single photon emission computed tomography (SPECT) ligand for the peripheral benzodiazepine receptor, the latter being expressed on microglia (brain resident macrophages) and upregulated under inflammatory circumstances. The objectives were to assess AD inflammation by detecting [[sup 123] I]iodo-PK11195 uptake changes and investigate how uptake values relate with perfusion SPECT and neuropsychological findings. Methods: Ten AD and 9 control subjects were included. [[sup 123] I]iodo-PK11195 SPECT images were realigned into stereotactic space where binding indices, normalized on cerebellar uptake, were calculated. Results: The mean [[sup 123] I]iodo-PK11195 uptake was increased in AD patients compared with controls in nearly all neocortical regions; however, statistical significance was only reached in the frontal and right mesotemporal regions. Significant correlations were found between regional increased [[sup 123] I]iodo-PK11195 uptake and cognitive deficits. Conclusions: [[sup 123] I]iodo-PK11195 is a cellular disease activity marker and allows in vivo assessment of microglial inflammation in AD.Copyright © 2003 S. Karger AG, Basel
- Subjects
ALZHEIMER'S disease; INFLAMMATION; MICROGLIA; BENZODIAZEPINE receptors; TOMOGRAPHY
- Publication
European Neurology, 2003, Vol 50, Issue 1, p39
- ISSN
0014-3022
- Publication type
Academic Journal
- DOI
10.1159/000070857