Assignment of the IκB-β gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization.

Okamoto, T.; Ono, T.; Hori, M.; Yang, J.-P.; Tetsuka, T.; Kawabe, T.; Sonta, S.

In this article, full-length of NFKBIB cDNA clone was isolated from a human placenta Matchmaker cDNA library by two-hybrid screening using yeast. The NFKBIB gene (alias IKBB, TRIP9) encodes the I&b.kappa;B-&b.beta; protein, an inhibitory molecule of transcription factor NF-&b.kappa;B. The I&b.kappa;B proteins comprise a distinct family including the following members: I&b.kappa;B-&b.alpha; and I&b.kappa;B-&b.beta;, which are cytoplasmic in location and inhibit the DNA binding of NF-&b.kappa;B; the product of the bcl-3 proto-oncogene, which is nuclear in location and inhibits the DNA-binding of NF-&b.kappa;B but, paradoxically, activates transcription when interacting with a homodimer complex of p50, one of the subunits of NF-&b.kappa;B; and the proteins corresponding to the C-terminal portions of p105 and p100, which are synthesized by alternative splicing of the respective genes and act as I&b.kappa;B molecules, thus named I&b.kappa;B-&b.gamma; and I&b.kappa;B-&b.delta;, respectively.

NF-kappa B; DNA; TRANSCRIPTION factors; PROTO-oncogenes; HUMAN chromosomes; IN situ hybridization; DNA-binding proteins

Cytogenetics & Cell Genetics, 1998, Vol 82, Issue 1/2, p105

0301-0171

Academic Journal

10.1159/000015077