Circular RNAs, miRNAs, and Exosomes: Their Roles and Importance in Amyloid‐Beta and Tau Pathologies in Alzheimer's Disease.

Pala, Mukaddes; Yilmaz, Senay Gorucu; Peña-Ortega, Fernando

Alzheimer's disease (AD) is a devastating neurodegenerative disorder. The pathology of this disease is based on two basic mechanisms: amyloid‐beta (Aβ) and tau fibrillation. Many genes and mechanisms have been identified as the primary causes of AD in clinical settings, and there have been exciting developments in drug treatments. Several molecules and biological structures regulate the genome outside of the standard DNA function. As in many diseases, circular RNAs (circRNAs), microRNAs (miRNAs), and exosomes (EXOs), investigated from different aspects of AD, are useful for treatment and diagnosis. This review examines two biological elements regarding their roles in the Aβ‐tau pathology of AD and their potential as treatment targets. Importantly, the activities of miRNAs that play a role in these processes were evaluated. Trial Registration: ClinicalTrials.gov identifiers: NCT04120493, NCT04969172, NCT04388982

BIOMOLECULES; CIRCULAR RNA; ALZHEIMER'S disease; PATHOLOGY; NEURODEGENERATION

Neural Plasticity, 2025, Vol 2025, p1

2090-5904

Academic Journal

10.1155/np/9581369