Works matching DE "SPHINGOSINE kinase"

Results: 385

FAM46C Expression Sensitizes Multiple Myeloma Cells to PF-543-Induced Cytotoxicity.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 623, doi. 10.3390/biom15050623

By:

Miluzio, Annarita;
De Grossi, Federica;
Mancino, Marilena;
Biffo, Stefano;
Manfrini, Nicola

Publication type:

Article

Lathyrol reduces the RCC invasion and incidence of EMT via affecting the expression of AR and SPHK2 in RCC mice.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01130-w

By:

Song, Shengyou;
Tai, Lunwei;
Xu, Yuqi;
Jiang, Junling;
Zhou, Lei;
Zhao, Junfeng

Publication type:

Article

The therapeutic effects of cycloastragenol in ulcerative colitis by modulating SphK/MIP‐1α/miR‐143 signalling.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 131, n. 5, p. 406, doi. 10.1111/bcpt.13788

By:

Bagalagel, Alaa;
Diri, Reem;
Noor, Ahmad;
Almasri, Deina;
Bakhsh, Hussain T.;
Kutbi, Hussam I.;
Al‐Gayyar, Mohammed M. H.

Publication type:

Article

Potential of a sphingosine 1-phosphate receptor antagonist and sphingosine kinase inhibitors as targets for multiple myeloma treatment.

Published in:

Oncology Letters, 2022, v. 23, n. 4, p. N.PAG, doi. 10.3892/ol.2022.13231

By:

Tanaka, Yuko;
Okabe, Seiichi;
Ohyashiki, Kazuma;
Gotoh, Akihiko

Publication type:

Article

Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.

Published in:

Oncology Letters, 2019, v. 18, n. 5, p. 5374, doi. 10.3892/ol.2019.10910

By:

Li, Jie;
Zhang, Bo;
Bai, Yang;
Liu, Yonghong;
Zhang, Buyong;
Jin, Jian

Publication type:

Article

Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer.

Published in:

Oncology Letters, 2017, v. 14, n. 1, p. 63, doi. 10.3892/ol.2017.6134

By:

YA‑JING ZHU;
ZHU QIU;
HONG‑ZHONG LI;
HONG‑YAN HUANG;
KE ZHENG;
GUO‑SHENG REN;
HUA YOU;
JIN‑XIANG TAN;
FAN LI

Publication type:

Article

Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma.

Published in:

Oncology Letters, 2017, v. 13, n. 4, p. 2316, doi. 10.3892/ol.2017.5732

By:

HUAJIE CAI;
XUEMENG XIE;
LING JI;
XIAOJIAO RUAN;
ZHIHAI ZHENG

Publication type:

Article

ATP release from erythrocytes: A role of adenosine1.

Published in:

Clinical Hemorheology & Microcirculation, 2022, v. 80, n. 2, p. 61, doi. 10.3233/CH-221379

By:

Misiti, Francesco;
Carelli-Alinovi, Cristiana;
Rodio, Angelo

Publication type:

Article

Berberine ameliorates erectile dysfunction in rats with streptozotocin‐induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.

Published in:

Andrology, 2022, v. 10, n. 2, p. 404, doi. 10.1111/andr.13119

By:

Liu, Kang;
Sun, Taotao;
Luan, Yang;
Chen, Yinwei;
Song, Jingyu;
Ling, Le;
Yuan, Penghui;
Li, Rui;
Cui, Kai;
Ruan, Yajun;
Lan, Ruzhu;
Wang, Tao;
Wang, Shaogang;
Liu, Jihong;
Rao, Ke

Publication type:

Article

A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids.

Published in:

Metabolites (2218-1989), 2020, v. 10, n. 6, p. 236, doi. 10.3390/metabo10060236

By:

Couttas, Timothy Andrew;
Rustam, Yepy Hardi;
Song, Huitong;
Qi, Yanfei;
Teo, Jonathan David;
Chen, Jinbiao;
Reid, Gavin Edmund;
Don, Anthony Simon

Publication type:

Article

Adiponectin Modulates Smooth Muscle Cell Morpho-Functional Properties in Murine Gastric Fundus via Sphingosine Kinase 2 Activation.

Published in:

Life (2075-1729), 2023, v. 13, n. 9, p. 1812, doi. 10.3390/life13091812

By:

Garella, Rachele;
Bernacchioni, Caterina;
Chellini, Flaminia;
Tani, Alessia;
Palmieri, Francesco;
Parigi, Martina;
Guasti, Daniele;
Cassioli, Emanuele;
Castellini, Giovanni;
Ricca, Valdo;
Bani, Daniele;
Sassoli, Chiara;
Donati, Chiara;
Squecco, Roberta

Publication type:

Article

Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01294

By:

Derakhshani, Shaghayegh;
Kurz, Andreas;
Japtok, Lukasz;
Schumacher, Fabian;
Pilgram, Lisa;
Steinke, Maria;
Kleuser, Burkhard;
Sauer, Markus;
Schneider-Schaulies, Sibylle;
Avota, Elita

Publication type:

Article

Roles of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor 2 in Endotoxin-Induced Acute Retinal Inflammation.

Published in:

Ocular Immunology & Inflammation, 2024, v. 32, n. 8, p. 1633, doi. 10.1080/09273948.2023.2273963

By:

Ahmed, Tazbir;
Suzuki, Takafumi;
Terao, Ryo;
Yamagishi, Reiko;
Fujino, Ryosuke;
Azuma, Kunihiro;
Soga, Hirotsugu;
Ueta, Takashi;
Honjo, Megumi;
Watanabe, Sumiko;
Yoshioka, Kazuaki;
Takuwa, Yoh;
Aihara, Makoto

Publication type:

Article

Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1.

Published in:

Oncogene, 2014, v. 33, n. 48, p. 5559, doi. 10.1038/onc.2013.502

By:

Pham, D H;
Powell, J A;
Gliddon, B L;
Moretti, P A B;
Tsykin, A;
Van der Hoek, M;
Kenyon, R;
Goodall, G J;
Pitson, S M

Publication type:

Article

Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells.

Published in:

Oncogene, 2014, v. 33, n. 26, p. 3364, doi. 10.1038/onc.2013.303

By:

Albinet, V;
Bats, M-L;
Huwiler, A;
Rochaix, P;
Chevreau, C;
Ségui, B;
Levade, T;
Andrieu-Abadie, N

Publication type:

Article

Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis.

Published in:

Oncogene, 2014, v. 33, n. 26, p. 3361, doi. 10.1038/onc.2013.292

By:

Pyne, N J;
Pyne, S

Publication type:

Article

Sphingosine 1‐Phosphate Prevents Human Embryonic Stem Cell Death Following Ischemic Injury.

Published in:

European Journal of Lipid Science & Technology, 2022, v. 124, n. 7, p. 1, doi. 10.1002/ejlt.202200019

By:

Assis, Juliane L. de;
Fernandes, Aline M.;
Aniceto, Bárbara S.;
Pompeu, Pedro;
Banchio, Claudia;
Girardini, Javier;
Vieyra, Adalberto;
Valverde, Rafael H. F.;
Einicker‐Lamas, Marcelo

Publication type:

Article

Role of Sphingosine Kinase in Type 2 Diabetes Mellitus.

Published in:

Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2020.627076

By:

Qi, Yanfei;
Wang, Wei;
Song, Ziyu;
Aji, Gulibositan;
Liu, Xin Tracy;
Xia, Pu

Publication type:

Article

Long Noncoding RNA LINC00460 Facilitates Colorectal Cancer Progression by Negatively Regulating miR-613.

Published in:

OncoTargets & Therapy, 2020, v. 13, p. 7555, doi. 10.2147/OTT.S254489

By:

Wang, Lei;
Chen, Xinxin;
Sun, Xuan;
Suo, Jian

Publication type:

Article

Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo.

Published in:

OncoTargets & Therapy, 2019, v. 12, p. 4437, doi. 10.2147/OTT.S208519

By:

Song, Keqi;
Dai, Lan;
Long, Xiaoran;
Cui, Xiaojuan;
Liu, Yixuan;
Di, Wen

Publication type:

Article

Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma.

Published in:

OncoTargets & Therapy, 2018, v. 11, p. 7187, doi. 10.2147/OTT.S180962

By:

Su, Lin;
Tian, Junyan;
Sun, Jinsong;
Han, Nuan;
Feng, Lin;
Yu, Baohua;
Wang, Yuepeng

Publication type:

Article

Transcriptional targeting of sphingosine-1-phosphate receptor S1P2 by epigallocatechin-3-gallate prevents sphingosine-1-phosphate-mediated signaling in macrophage-differentiated HL-60 promyelomonocytic leukemia cells.

Published in:

OncoTargets & Therapy, 2014, v. 7, p. 667, doi. 10.2147/OTT.S62717

By:

Chokor, Rima;
Lamy, Sylvie;
Annabi, Borhane

Publication type:

Article

Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0213917

By:

Santacreu, Bruno Jaime;
Pescio, Lucila Gisele;
Romero, Daniela Judith;
Corradi, Gerardo Raúl;
Sterin-Speziale, Norma;
Favale, Nicolás Octavio

Publication type:

Article

Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells.

Published in:

PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0203211

By:

Kawa, Yoshitaka;
Nagano, Tatsuya;
Yoshizaki, Asuka;
Dokuni, Ryota;
Katsurada, Masahiro;
Terashita, Tomomi;
Yasuda, Yuichiro;
Umezawa, Kanoko;
Yamamoto, Masatsugu;
Kamiryo, Hiroshi;
Kobayashi, Kazuyuki;
Nishimura, Yoshihiro

Publication type:

Article

Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.

Published in:

PLoS ONE, 2018, v. 13, n. 3, p. 1, doi. 10.1371/journal.pone.0194053

By:

Ghosh, Mallika;
Thangada, Shobha;
Dasgupta, Oisharya;
Khanna, Kamal M.;
Yamase, Harold T.;
Kashgarian, Michael;
Hla, Timothy;
Shapiro, Linda H.;
Ferrer, Fernando A.

Publication type:

Article

Sphingosine kinase 2-deficiency mediated changes in spinal pain processing.

Published in:

Frontiers in Molecular Neuroscience, 2015, v. 8, p. 1, doi. 10.3389/fnmol.2015.00029

By:

Canlas, Jastrow;
Holt, Phillip;
Carroll, Alexander;
Rix, Shane;
Ryan, Paul;
Davies, Lorena;
Matusica, Dusan;
Pitson, Stuart M.;
Jessup, Claire F.;
Gibbins, Ian L.;
Haberberger, Rainer V.

Publication type:

Article

Sphingosine kinase 2-deficiency mediated changes in spinal pain processing.

Published in:

Frontiers in Molecular Neuroscience, 2015, p. 1, doi. 10.3389/fnmol.2015.00029

By:

Canlas, Jastrow;
Holt, Phillip;
Carroll, Alexander;
Rix, Shane;
Ryan, Paul;
Davies, Lorena;
Matusica, Dusan;
Pitson, Stuart M.;
Jessup, C.;
Gibbins, Ian L.;
Haberberger, Rainer V.

Publication type:

Article

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.

Published in:

Nature Medicine, 2014, v. 20, n. 8, p. 927, doi. 10.1038/nm.3610

By:

Yamane, Daisuke;
McGivern, David R;
Wauthier, Eliane;
Yi, MinKyung;
Madden, Victoria J;
Welsch, Christoph;
Antes, Iris;
Wen, Yahong;
Chugh, Pauline E;
McGee, Charles E;
Widman, Douglas G;
Misumi, Ichiro;
Bandyopadhyay, Sibali;
Kim, Seungtaek;
Shimakami, Tetsuro;
Oikawa, Tsunekazu;
Whitmire, Jason K;
Heise, Mark T;
Dittmer, Dirk P;
Kao, C Cheng

Publication type:

Article

Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2020, v. 62, n. 1, p. 35, doi. 10.1165/rcmb.2018-0397OC

By:

Blais-Lecours, Pascale;
Laouafa, Sofien;
Arias-Reyes, Christian;
Santos, Webster L.;
Joseph, Vincent;
Burgess, Janette K.;
Halayko, Andrew J.;
Soliz, Jorge;
Marsolais, David

Publication type:

Article

Drug Resistance: The Role of Sphingolipid Metabolism.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 8, p. 3716, doi. 10.3390/ijms26083716

By:

Zhakupova, Assem;
Zeinolla, Adelina;
Kokabi, Kamilya;
Sergazy, Shynggys;
Aljofan, Mohamad

Publication type:

Article

Immunomodulatory Effects of SPHK1 and Its Interaction with TFAP2A in Yellow Drum (Nibea albiflora).

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 24, p. 13641, doi. 10.3390/ijms252413641

By:

Cui, Yu;
Luo, Shuai;
Wu, Baolan;
Li, Qiaoying;
Han, Fang;
Wang, Zhiyong

Publication type:

Article

Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.

Published in:

Cancer Cell International, 2014, v. 14, n. 1, p. 1, doi. 10.1186/s12935-014-0076-x

By:

Tamashiro, Paulette M.;
Furuya, Hideki;
Shimizu, Yoshiko;
Toshihiko Kawamori

Publication type:

Article

Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte.

Published in:

Molecular & Cellular Biochemistry, 2015, v. 401, n. 1/2, p. 39, doi. 10.1007/s11010-014-2290-1

By:

Matsuzaki, Etsuko;
Hashimoto, Yoko;
Higashi, Katsumasa;
Takano, Aiko;
Nishimura, Fusanori;
Takahashi-Yanaga, Fumi;
Hirata, Masato

Publication type:

Article

High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2.

Published in:

Molecular & Cellular Biochemistry, 2014, v. 389, n. 1/2, p. 197, doi. 10.1007/s11010-013-1941-y

By:

Xiong, Sheng-Lin;
Liu, Xing;
Yi, Guang-Hui

Publication type:

Article

Sphingosine kinase 1 inhibition aggravates vascular smooth muscle cell calcification.

Published in:

Pflügers Archiv: European Journal of Physiology, 2025, v. 477, n. 6, p. 815, doi. 10.1007/s00424-025-03068-6

By:

Razazian, Mehdi;
Bahiraii, Sheyda;
Jannat, Isratul;
Tiffner, Adéla;
Beilhack, Georg;
Levkau, Bodo;
Voelkl, Jakob;
Alesutan, Ioana

Publication type:

Article

The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 12, p. 1845, doi. 10.1007/s00424-024-03029-5

By:

Schwalm, Stephanie;
Manaila, Roxana;
Oftring, Anke;
Schaefer, Liliana;
von Gunten, Stephan;
Pfeilschifter, Josef

Publication type:

Article

A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-1.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 12, p. 1895, doi. 10.1007/s00424-024-03027-7

By:

Volk, Luisa Michelle;
Bruun, Jan-Erik;
Trautmann, Sandra;
Thomas, Dominique;
Schwalm, Stephanie;
Pfeilschifter, Josef;
zu Heringdorf, Dagmar Meyer

Publication type:

Article

Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer.

Published in:

Journal of Cancer Research & Clinical Oncology, 2017, v. 143, n. 4, p. 601, doi. 10.1007/s00432-016-2315-0

By:

Liang, Weiwei;
Xie, Zhiwei;
Cui, Weiling;
Guo, Yan;
Xu, Lijuan;
Wu, Jueheng;
Guan, Hongyu

Publication type:

Article

Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer.

Published in:

Journal of Cancer Research & Clinical Oncology, 2013, v. 139, n. 10, p. 1681, doi. 10.1007/s00432-013-1490-5

By:

Ruckhäberle, Eugen;
Karn, Thomas;
Denkert, Carsten;
Loibl, Sibylle;
Ataseven, Beyhan;
Reimer, Toralf;
Becker, Sven;
Holtrich, Uwe;
Rody, Achim;
Darb-Esfahani, Silvia;
Nekljudova, Valentina;
Minckwitz, Gunter

Publication type:

Article

Discovery of an SphK1 inhibitor: A hybrid approach involving a receptor–ligand-complex-based pharmacophore and docking-based virtual screening.

Published in:

Journal of Chemical Research, 2022, v. 46, n. 2, p. 1, doi. 10.1177/17475198221089222

By:

Ding, Tiandi;
Chen, HaiJiao;
Li, Yan;
Li, Ying;
Zhi, Ying;
Qu, Zhiqiang;
Sun, Qiang;
Yao, Qingqiang;
Liu, Bo

Publication type:

Article

L-ascorbyl 6-palmitate as lead compound targeting SphK1: an in silico and in vitro investigation.

Published in:

Journal of Chemical Research, 2021, v. 45, p. 781, doi. 10.1177/17475198211001819

By:

Chen, HaiJiao;
Yang, Xinmei;
Sun, Peng;
Zhi, Ying;
Yao, Qingqiang;
Liu, Bo

Publication type:

Article

Preclinical evidence of sphingosine kinase 1 inhibition in alleviation of intestinal epithelial injury in polymicrobial sepsis.

Published in:

Inflammation Research, 2019, v. 68, n. 9, p. 723, doi. 10.1007/s00011-019-01255-7

By:

Ugwu, Felix Nnaemeka;
Ho, Jeffery

Publication type:

Article

亚砷酸钠对人脐静脉内皮细胞损伤及鞘氨醇激酶 1/1- 磷酸鞘氨醇信号轴的影响.

Published in:

Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2023, v. 27, n. 26, p. 4161, doi. 10.12307/2023.121

By:

方兴艳;
田侦丽;
赵哲仪;
文平;
谢婷婷

Publication type:

Article

Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-08011-8

By:

Martín-Hernández, David;
Gutiérrez, Irene L.;
González-Prieto, Marta;
MacDowell, Karina S.;
Robledo-Montaña, Javier;
Tendilla-Beltrán, Hiram;
Calleja-Rodríguez, Natalia;
Bris, Álvaro G.;
Ulecia-Morón, Cristina;
Moreno, Beatriz;
Caso, Javier R.;
García-Bueno, Borja;
Rodrigues-Mascarenhas, Sandra;
Marín-Jiménez, Ignacio;
Leza, Juan Carlos;
Menchén, Luis

Publication type:

Article

Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94052-4

By:

Liu, Haonan;
Jackson, Molly L.;
Goudswaard, Lucy J.;
Moore, Samantha F.;
Hutchinson, James L.;
Hers, Ingeborg

Publication type:

Article

Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma.

Published in:

Cells (2073-4409), 2020, v. 9, n. 4, p. 1030, doi. 10.3390/cells9041030

By:

Lee, Michael S.;
Sun, Wenji;
Webb, Tonya J.

Publication type:

Article

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.

Published in:

Cells (2073-4409), 2020, v. 9, n. 4, p. 886, doi. 10.3390/cells9040886

By:

Hii, Ling-Wei;
Chung, Felicia Fei-Lei;
Mai, Chun Wai;
Yee, Zong Yang;
Chan, Hong Hao;
Raja, Vijay Joseph;
Dephoure, Noah Elias;
Pyne, Nigel J.;
Pyne, Susan;
Leong, Chee-Onn

Publication type:

Article

High Dose C6 Ceramide-Induced Response in Embryonic Hippocampal Cells.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 3, p. 430, doi. 10.3390/biom15030430

By:

Fiorani, Federico;
Mandarano, Martina;
Cataldi, Samuela;
Mirarchi, Alessandra;
Bruscoli, Stefano;
Ragonese, Francesco;
Fioretti, Bernard;
Kobayashi, Toshihide;
Tomishige, Nario;
Beccari, Tommaso;
Floridi, Claudia;
Arcuri, Cataldo;
Albi, Elisabetta

Publication type:

Article

Sphingosine-1-phosphate inhibitors are potential therapeutic targets for pulmonary arterial hypertension.

Published in:

2015

By:

Bhavanam, Naga P.;
Failla, Athena;
Young Cho;
Lockey, Richard F.;
Kolliputi, Narasaiah

Publication type:

Opinion

Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.

Published in:

Carcinogenesis, 2017, v. 38, n. 12, p. 1218, doi. 10.1093/carcin/bgx104

By:

Hideki Furuya;
Paulette M. Tamashiro;
Yoshiko Shimizu;
Kayoko Iino;
Peres, Rafael;
Runpu Chen;
Yijun Sun;
Yusuf A. Hannun;
Lina M. Obeid;
Toshihiko Kawamori

Publication type:

Article