Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism.

Vidal, Angela; Dhakal, Carolin

Thalassaemic syndromes are among the most common haemoglobinopathies and are associated with high morbidity and mortality. Because of the various treatments, a secondary endocrinopathy due to iron overload—haemosiderosis—can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency.

BETA-Thalassemia; HYPOGONADISM; PREMATURE ovarian failure; IRON overload; BONE marrow transplantation; HYPOPITUITARISM; PREMATURE menopause

Case Reports in Obstetrics & Gynecology, 2022, p1

2090-6684

Academic Journal

10.1155/2022/4655249