Results
Title

Role of Different Types of miRNAs in Some Cardiovascular Diseases and Therapy-Based miRNA Strategies: A Mini Review.

Authors

Fayez, Safa S.; Mishlish, Sami Mukhlif; Saied, Hanan M.; Shaban, Semaa A.; Suleiman, Ahmed AbdulJabbar; Hassan, Firas; Al-Saffar, Ali Z.; Al-Obaidi, Jameel R.

Abstract

The role of microRNAs (miRNAs) in the pathogenesis of cardiovascular disease has been extensively studied. miRNAs have been highlighted as an important physiological regulator for activities like cardiac protection. miRNAs are present in the circulation, and they have been investigated as physiological markers, especially in the condition of heart failure. However, there is less compelling verification that miRNAs can outperform traditional biomarkers. However, clinical evidence is still required. In this review article, we explored the feasibility of miRNAs as diagnostic biomarkers for heart failure in a systematic study. Searching in the PubMed database to identify miRNA molecules that are differentially expressed between groups of patients with heart failure or heart disease and controls, throughout the investigation, we discovered no significant overlap in differentially expressed miRNAs. Only four miRNAs ("miR-126," "miR-150-5p," "hsa-miR-233," and "miR-423-5p") were differentially expressed. Results from our review show that there is not enough evidence to support the use of miRNAs as biomarkers in clinical settings.

Subjects

CARDIOVASCULAR disease treatment; ONLINE information services; SYSTEMATIC reviews; MESSENGER RNA; MEDLINE

Publication

BioMed Research International, 2022, Vol 2022, p1

ISSN

2314-6133

Publication type

Academic Journal

DOI

10.1155/2022/2738119