Results
Title

The Effects of Probiotic Supplementation on Opioid-Related Disorder in Patients under Methadone Maintenance Treatment Programs.

Authors

Molavi, Nader; Rasouli-Azad, Morad; Mirzaei, Hamed; Matini, Amir Hassan; Banafshe, Hamid Reza; Valiollahzadeh, Marjan; Hassanzadeh, Majid; Saghazade, Ahmad Reza; Abbaszadeh-Mashkani, Samira; Mamsharifi, Peyman; Ghaderi, Amir

Abstract

Introduction: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and serum lipid content in patients receiving MMTPs.Materials and Methods: A randomized, double-blind, placebo-controlled trial was conducted among 70 patients receiving MMTPs to receive either 1.8 × 109 CFU/day probiotics (n = 35) or placebo (n = 35) for 12 weeks. Clinical symptoms and metabolic profiles were measured before and after the intervention in patients receiving MMTPs.Results: Compared with the placebo group, probiotic supplementation resulted in a significant improvement in the severity of depression (P Conclusion: Treatment with probiotics for 12 weeks to patients receiving MMTPs had beneficial effects on symptoms of depression, as well as several metabolic profiles. Clinical Trial Registration: this study was registered in the Iranian website (https://www.irct.ir) for clinical trials registration (https://fa.irct.ir/trial/46363/IRCT20170420033551N9). The registration date is March 22, 2020.

Publication

International Journal of Clinical Practice, 2022, p1

ISSN

1368-5031

Publication type

Academic Journal

DOI

10.1155/2022/1206914