Results
Title

Circular RNAs in Cardiovascular Disease: An Overview.

Authors

Fan, Ximin; Weng, Xinyu; Zhao, Yifan; Chen, Wei; Gan, Tianyi; Xu, Dachun

Abstract

Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.

Subjects

CIRCULAR RNA; ATHEROSCLEROSIS risk factors; RNA physiology; BIOMARKERS; CARDIOVASCULAR diseases; GENE expression; GENETICS; CARDIAC hypertrophy; HEART failure; MYOCARDIAL infarction; RNA; PHENOMENOLOGICAL biology

Publication

BioMed Research International, 2017, Vol 2017, p1

ISSN

2314-6133

Publication type

Academic Journal

DOI

10.1155/2017/5135781