Results
Title

Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?

Authors

Pongpit, Jamrus; Porntharukchareon, Saneerat; Kaewduang, Piyaporn; Promson, Kwannapa; Stitchantrakul, Wasana; Petraksa, Supanna; Thakkinstian, Ammarin; Kositchaiwat, Chomsri; Rajatanavin, Natta; Sobhonslidsuk, Abhasnee

Abstract

Background. An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver fibrosis or high liver stiffness measurement (LSM) using the LSM cutoff over 7 kPa and its associated factors in psoriatic patients. Methods. Subjects underwent TE and ultrasonography. Univariate and multivariate analysis were performed for the associated factors. Results. One hundred and sixty-eight patients were recruited. Three patients were excluded due to TE failure. Mean BMI was 24.8 ± 4.7 kg/m². NAFLD, metabolic syndrome, and diabetes were seen in 105 (63.6%), 83 (50.3%), and 31 (18.8%) patients. The total cumulative dose of methotrexate over 1.5 g was seen in 39 (23.6%) patients. Mean LSMwas 5.3±2.9 kPa. High LSMwas found in 18 (11.0%) patients. Waist circumference (OR: 1.24; 95% CI: 1.11-1.38; 𝑃 = 0.0002), diabetes (OR: 12.70; 95% CI: 1.84-87.70; 𝑃 = 0.010), and AST (OR: 1.08; 95% CI: 1.02-1.16; 𝑃 = 0.017) were associated with high LSM. Conclusion. 11% of psoriatic patients had significant liver fibrosis by high LSM.Waist circumference, diabetes, and AST level were the independent predictors.

Subjects

BIOMARKERS; CONFIDENCE intervals; DIABETES; DIAGNOSTIC errors; FATTY liver; HEPATOTOXICOLOGY; CIRRHOSIS of the liver; METHOTREXATE; MULTIVARIATE analysis; PSORIASIS; STATISTICS; METABOLIC syndrome; ALANINE aminotransferase; BODY mass index; DISEASE prevalence; WAIST circumference; ODDS ratio

Publication

BioMed Research International, 2016, Vol 2016, p1

ISSN

2314-6133

Publication type

Academic Journal

DOI

10.1155/2016/7963972