Results
Title

Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation.

Authors

Sevindik, Ömür Gökmen; Alacacıoğlu, İnci; Katgı, Abdullah; Solmaz, Şerife Medeni; Acar, Celal; Pişkin, Özden; Özcan, Mehmet Ali; Demirkan, Fatih; Ündar, Bülent; Özsan, Güner Hayri

Abstract

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation.

Subjects

THROMBOTIC thrombocytopenic purpura treatment; NEUROLOGY; ECULIZUMAB; PROGENITOR cells; HEMATOPOIETIC stem cell transplantation; STIMULUS & response (Biology); THERAPEUTICS

Publication

Case Reports in Hematology, 2015, Vol 2015, p1

ISSN

2090-6560

Publication type

Academic Journal

DOI

10.1155/2015/425410