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Title

Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans.

Authors

Mu Yuan; Ming-Zhu Bai; Xu-Feng Huang; Yue Zhang; Jing Liu; Min-Hao Hu; Wei-Qian Zheng; Fan Jin; Yuan, Mu; Bai, Ming-Zhu; Huang, Xu-Feng; Zhang, Yue; Liu, Jing; Hu, Min-Hao; Zheng, Wei-Qian; Jin, Fan

Abstract

Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.

Subjects

BISPHENOL A; TRICLOSAN; ENDOCRINE system; ENDOCRINE disruptors; CHEMICAL structure; PHARMACOKINETICS; LABORATORY mice; FERTILIZATION in vitro

Publication

BioMed Research International, 2015, Vol 2015, p1

ISSN

2314-6133

Publication type

Academic Journal

DOI

10.1155/2015/184845

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