Results
Title

Evaluation of Antiarthritic Potential of Methanolic Extract of Gentiana kurroo Royle.

Authors

Khan, Mubashir; Ganai, Bashir A.; Ghazanfar, Khalid; Akbar, Seema

Abstract

Rheumatoid arthritis is a systemic disorderwhich involves the activation of immune systemagainst the self-tissues. The main targets of this disease are the joints. Being systemic the development of this disease involves differentmechanisms and thus the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure for this disease. In the current study the rat carrageenin paw was used as a model for acute inflammation and mycobacterium induced adjuvant arthriticmodel was used for exploring the antiarthritic potential ofmethanolic extract of Gentiana kurroo. In this study the different extracts tested showed less inhibition of acute inflammation than methanolic extract. The methanolic extract was further used in different doses and the anti-inflammatory efficacy was found to be dose dependent. The results obtained were significant with the control and the standard groups. In the arthritic model the methanolic extract showed decrease in the paw volume of arthritic animals and also in the arthritic symptoms. Again the results obtained were found to be significantly dose dependent. From the results obtained it can be concluded that this extract may serve as a source of drug against the rheumatoid arthritis.

Subjects

ANTIARTHRITIC agents; IMMUNE system; INFLAMMATION; LABORATORY rats; METHANOL; RHEUMATOID arthritis

Publication

Arthritis (20901984), 2014, p1

ISSN

2090-1984

Publication type

Academic Journal

DOI

10.1155/2014/810615