Title: Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2- chlorobenzyloxyimino) Ethyl Ciprofloxacin Derivatives.
Authors: ALIPOUR, ESKANDAR; MOHAMMADHOSSEINI, NEGAR; PANAH, FATEMEH; ARDESTANI, SUSSAN K.; SAFAVI, MALIHEH; SHAFIEE, ABBAS; FOROUMADI, ALIREZA
Abstract: Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N-pipearzinyl quinolones containing N- 2-(furyl-2-yl)-2-(chlorobenzyloxyimino) ethyl moiety (6a-c) have been studied. Preliminary screening showed that one of the new compounds, namely 7-(4-(2- (3-chlorobenzyloxyimino)-2-(furan-2-yl) ethyl) piperazin-1-yl)-1-cyclopropyl- 6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6b) showed significant cytotoxic activity against human breast tumor cell lines.
Subjects: CIPROFLOXACIN; DNA topoisomerases; QUINOLONE antibacterial agents; DNA replication; THIN layer chromatography; SPECTROPHOTOMETERS; POTASSIUM bromide
Publication: E-Journal of Chemistry, 2011, Vol 8, Issue 3, p1226
ISSN: 0973-4945
Publication type: Academic Journal
DOI: 10.1155/2011/842982

Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2- chlorobenzyloxyimino) Ethyl Ciprofloxacin Derivatives.

ALIPOUR, ESKANDAR; MOHAMMADHOSSEINI, NEGAR; PANAH, FATEMEH; ARDESTANI, SUSSAN K.; SAFAVI, MALIHEH; SHAFIEE, ABBAS; FOROUMADI, ALIREZA