The independence number of a graph G , denoted by α (G) , is the maximum cardinality of an independent set of vertices in G. [Henning and Löwenstein An improved lower bound on the independence number of a graph, Discrete Applied Mathematics 179 (2014) 120–128.] proved that if a connected graph G of order n and size m does not belong to a specific family of graphs, then α (G) > 2 3 n − 1 4 m. In this paper, we strengthen the above bound for connected graphs with maximum degree at least three that have a non-cut-vertex of maximum degree. We show that if a connected graph G of order n and size m has a non-cut-vertex of maximum degree then α (G) ≥ 2 3 n − 1 4 (m − Δ (G)) − 1 1 1 2 , where Δ (G) is the maximum degree of the vertices of G. We also characterize all connected graphs G of order n and size m that have a non-cut-vertex of maximum degree and α (G) ≤ 2 3 n − 1 4 (m − Δ (G)) − 2 3 .