Works matching DE "GENE knockout"

Results: 1277

Targeted inhibition of PDGFRA with avapritinib, markedly enhances lenvatinib efficacy in hepatocellular carcinoma in vitro and in vivo: clinical implications.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-025-03386-8

By:

Zhao, Bixing;
Zhou, Yang;
Cheng, Niangmei;
Zheng, Xiaoyuan;
Chen, Geng;
Qi, Xin;
Zhang, Xiangzhi;
Wang, Fei;
Zhuang, Qiuyu;
Assaraf, Yehuda G.;
Liu, Xiaolong;
Wang, Yingchao;
Zeng, Yongyi

Publication type:

Article

酿酒酵母中苯丙氨酸合成黄芩素的途径构建与优化.

Published in:

China Brewing, 2025, v. 44, n. 4, p. 112, doi. 10.11882/j.issn.0254-5071.2025.04.016

By:

王舜;
王鉴;
汪方奕;
于潇洁;
江会峰;
何如怡;
田宇;
刘志国

Publication type:

Article

OTUD1 Deficiency Alleviates LPS-Induced Acute Lung Injury in Mice by Reducing Inflammatory Response.

Published in:

Inflammation, 2025, v. 48, n. 2, p. 649, doi. 10.1007/s10753-024-02074-7

By:

Zhu, Weiwei;
Zhang, Qianhui;
Jin, Leiming;
Lou, Shuaijie;
Ye, Jiaxi;
Cui, Yaqian;
Xiong, Yongqiang;
Lin, Mengsha;
Liang, Guang;
Luo, Wu;
Zhuang, Zaishou

Publication type:

Article

RNA-seq analysis reveals key genes associated with downregulation of APE1 in esophageal squamous cell carcinoma.

Published in:

Frontiers in Genetics, 2025, p. 1, doi. 10.3389/fgene.2025.1549371

By:

Chu, Alan;
Liu, Xiao;
Liu, Shijia;
Li, Mengxi;
Song, Rui;
Gan, Lanlan;
Wang, Yongtai;
Liu, Zongwen;
Sun, Chen

Publication type:

Article

Carbohydrate sulfotransferase 14 gene deletion induces dermatan sulfate deficiency and affects collagen structure and bowel contraction.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0320943

By:

Ono, Fumiko;
Takahashi, Yuki;
Shimada, Shin;
Mizumoto, Shuji;
Miyata, Shinji;
Nitahara-Kasahara, Yuko;
Yamada, Shuhei;
Okada, Takashi;
Kosho, Tomoki;
Yoshizawa, Takahiro

Publication type:

Article

Recurrence of acute allergic asthma depends on the role of ILC2 driven by Il1rl1 signaling.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02220-0

By:

Gan, Hui;
Huang, Zhifeng;
Pan, Qingjun;
Ye, Fei;
Zhu, Zheng;
Sun, Baoqing

Publication type:

Article

Study of Hsp90α and Hsp90β role in virus replication using cell lines with Hsp90 gene knockouts.

Published in:

Virus Genes, 2025, v. 61, n. 3, p. 277, doi. 10.1007/s11262-025-02141-7

By:

Bieganowski, Pawel;
Dalidowska, Iga;
Gazi, Olga;
Guzowska, Magdalena;
Przybylski, Maciej

Publication type:

Article

BENIN: Biologically enhanced network inference.

Published in:

Journal of Bioinformatics & Computational Biology, 2020, v. 18, n. 3, p. N.PAG, doi. 10.1142/S0219720020400077

By:

Wonkap, Stephanie Kamgnia;
Butler, Gregory

Publication type:

Article

SIN-KNO: A method of gene regulatory network inference using single-cell transcription and gene knockout data.

Published in:

Journal of Bioinformatics & Computational Biology, 2019, v. 17, n. 6, p. N.PAG, doi. 10.1142/S0219720019500355

By:

Wang, Huiqing;
Lian, Yuanyuan;
Li, Chun;
Ma, Yue;
Yan, Zhiliang;
Dong, Chunlin

Publication type:

Article

A study of structural properties of gene network graphs for mathematical modeling of integrated mosaic gene networks.

Published in:

Journal of Bioinformatics & Computational Biology, 2017, v. 15, n. 2, p. -1, doi. 10.1142/S0219720016500451

By:

Petrovskaya, Olga V.;
Petrovskiy, Evgeny D.;
Lavrik, Inna N.;
Ivanisenko, Vladimir A.

Publication type:

Article

KpsS1 Mediates the Glycosylation of Pseudaminic Acid in Acinetobacter Baumannii.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 41, p. 1, doi. 10.1002/chem.202400703

By:

Cheung, Yan Chu;
Guo, Xing;
Yang, Xuemei;
Wei, Ruohan;
Chan, Edward Waichi;
Li, Xuechen;
Chen, Sheng

Publication type:

Article

Knockout and functional analysis of BSSS-related genes in Acremonium chrysogenum by novel episomal expression vector containing Cas9 and AMA1.

Published in:

Biotechnology Letters, 2022, v. 44, n. 5/6, p. 755, doi. 10.1007/s10529-022-03255-w

By:

Liu, Ling;
Chen, Zhen;
Tian, Xiwei;
Chu, Ju

Publication type:

Article

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells.

Published in:

Biotechnology Letters, 2022, v. 44, n. 1, p. 59, doi. 10.1007/s10529-021-03214-x

By:

Zhu, Xiang-xing;
Pan, Jia-sheng;
Lin, Tao;
Yang, Ye-cheng;
Huang, Qiu-yan;
Yang, Shuai-peng;
Qu, Zi-xiao;
Lin, Zi-sheng;
Wen, Jian-cong;
Yan, Ai-fen;
Feng, Juan;
Liu, Lian;
Zhang, Xiao-li;
Lu, Jia-hong;
Tang, Dong-sheng

Publication type:

Article

Genome editing of Corynebacterium glutamicum mediated with Cpf1 plus Ku/LigD.

Published in:

Biotechnology Letters, 2021, v. 43, n. 12, p. 2273, doi. 10.1007/s10529-021-03195-x

By:

Yang, Fa-Yu;
Wei, Nan;
Zhang, Zhi-Hao;
Wang, Mi;
Liu, Ying-Chun;
Zhang, Li-Fang;
Gu, Feng

Publication type:

Article

Enhanced rhamnolipids production in Pseudomonas aeruginosa SG by selectively blocking metabolic bypasses of glycosyl and fatty acid precursors.

Published in:

Biotechnology Letters, 2020, v. 42, n. 6, p. 997, doi. 10.1007/s10529-020-02838-9

By:

Lei, Liying;
Zhao, Feng;
Han, Siqin;
Zhang, Ying

Publication type:

Article

Generation of ΔF508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editing.

Published in:

Biotechnology Letters, 2016, v. 38, n. 12, p. 2023, doi. 10.1007/s10529-016-2190-4

By:

Chung, Woo;
Kim, Hyongbum;
Lee, Min;
Kim, Joo;
Song, Myungjae;
Park, Jinhong;
Namkung, Wan;
Lee, Jinu

Publication type:

Article

Functional analysis of alcohol dehydrogenase ( ADH) genes in Pichia pastoris.

Published in:

Biotechnology Letters, 2016, v. 38, n. 3, p. 463, doi. 10.1007/s10529-015-1993-z

By:

Karaoglan, Mert;
Karaoglan, Fidan;
Inan, Mehmet

Publication type:

Article

Cardioprotective effect of thyroid hormone is mediated by AT2 receptor and involves nitric oxide production via Akt activation in mice.

Published in:

Heart & Vessels, 2018, v. 33, n. 6, p. 671, doi. 10.1007/s00380-017-1101-5

By:

da Silva, Ivson Bezerra;
Gomes, Dayane Aparecida;
Alenina, Natalia;
Bader, Michael;
dos Santos, Robson Augusto;
Barreto-Chaves, Maria Luiza M.

Publication type:

Article

Knockout mouse models of Hirschsprung's disease.

Published in:

Pediatric Surgery International, 2015, v. 31, n. 9, p. 787, doi. 10.1007/s00383-015-3747-3

By:

Zimmer, J.;
Puri, P.

Publication type:

Article

Low-temperature embryo incubation suppresses off-target mutagenesis during CRISPR-Cas9 genome editing in medaka (Oryzias latipes) and zebrafish (Danio rerio).

Published in:

Transgenic Research, 2025, v. 34, n. 1, p. 1, doi. 10.1007/s11248-025-00434-z

By:

Yamanaka, Takashi;
Sogo, Akiko;
Maegawa, Shingo;
Kinoshita, Masato

Publication type:

Article

Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1.

Published in:

Transgenic Research, 2020, v. 29, n. 4, p. 419, doi. 10.1007/s11248-020-00211-0

By:

Yu, Jinfeng;
Dong, Jiale;
Chen, Kangdi;
Ding, Yaping;
Yang, Zhicheng;
Lan, Tian

Publication type:

Article

Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout.

Published in:

Transgenic Research, 2018, v. 27, n. 3, p. 241, doi. 10.1007/s11248-018-0069-y

By:

Lee, Jae Hoon;
Park, Jong-Hyung;
Nam, Tae-Wook;
Seo, Sun-Min;
Kim, Jun-Young;
Lee, Han-Kyul;
Han, Jong Hyun;
Park, Song Yi;
Choi, Yang-Kyu;
Lee, Han-Woong

Publication type:

Article

CRISPR/Cas9-mediated knockout of myostatin in Chinese indigenous Erhualian pigs.

Published in:

Transgenic Research, 2017, v. 26, n. 6, p. 799, doi. 10.1007/s11248-017-0044-z

By:

Wang, Kankan;
Tang, Xiaochun;
Xie, Zicong;
Zou, Xiaodong;
Li, Mengjing;
Yuan, Hongming;
Guo, Nannan;
Ouyang, Hongsheng;
Jiao, Huping;
Pang, Daxin

Publication type:

Article

Attenuated Strain of Mycobacterium tuberculosis BN: Characteristics.

Published in:

Bulletin of Experimental Biology & Medicine, 2023, v. 174, n. 3, p. 341, doi. 10.1007/s10517-023-05705-5

By:

Nikonenko, B. V.;
Donnikov, A. E.;
Logunova, N. N.;
Sterzhanova, N. V.;
Shchelykalina, S. P.;
Kayukova, S. I.

Publication type:

Article

Deficiency of Urokinase-Type Plasminogen Activator Receptor Is Associated with the Development of Perivascular Fibrosis in Mouse Heart.

Published in:

Bulletin of Experimental Biology & Medicine, 2022, v. 173, n. 1, p. 5, doi. 10.47056/0365-9615-2022-173-1-11-15

By:

Dergilev, K. V.;
Beloglazova, I. B.;
Tsokolaeva, Z. I.;
Vasilets, Yu. D.;
Parfenova, E. V.

Publication type:

Article

Electrophysiological Features of Single Store-Operated Calcium Channels in HEK S4 Cell Line with Stable STIM1 Protein Knockdown.

Published in:

Bulletin of Experimental Biology & Medicine, 2017, v. 163, n. 3, p. 326, doi. 10.1007/s10517-017-3795-x

By:

Shalygin, A.;
Vigont, V.;
Glushankova, L.;
Zimina, O.;
Kolesnikov, D.;
Skopin, A.;
Kaznacheeva, E.

Publication type:

Article

Molecular mechanism of reduced biological fitness of fludioxonil‐resistant strains of Botrytis cinerea based on transcriptome analysis.

Published in:

Pest Management Science, 2024, v. 80, n. 9, p. 4746, doi. 10.1002/ps.8191

By:

Yin, Xueru;
Wang, Zongwei;
Wang, Jing;
Fang, Anfei;
Tian, Binnian;
Yang, Yuheng;
Yu, Yang;
Bi, Chaowei

Publication type:

Article

CRISPR/Cas9‐mediated knockout of NlCYP6CS1 gene reveals its role in detoxification of insecticides in Nilaparvata lugens (Hemiptera: Delphacidae).

Published in:

Pest Management Science, 2023, v. 79, n. 6, p. 2239, doi. 10.1002/ps.7404

By:

Zhang, Yan‐Chao;
Gao, Yang;
Ye, Wen‐Nan;
Peng, Yu‐Xuan;
Zhu, Kun Yan;
Gao, Cong‐Fen

Publication type:

Article

Utilization of a strong promoter combined with the knockout of protease genes to improve the yield of Vip3Aa in Bacillus thuringiensisBMB171.

Published in:

Pest Management Science, 2023, v. 79, n. 5, p. 1713, doi. 10.1002/ps.7343

By:

Li, Xuelian;
Zhang, Yanli;
Zhan, Yunda;
Tian, Hongwei;
Yan, Bing;
Cai, Jun

Publication type:

Article

CRISPR‐mediated gene knockout reveals nicotinic acetylcholine receptor (nAChR) subunit α6 as a target of spinosyns in Helicoverpa armigera.

Published in:

Pest Management Science, 2020, v. 76, n. 9, p. 2925, doi. 10.1002/ps.5889

By:

Wang, Jing;
Ma, Huanhuan;
Zuo, Yayun;
Yang, Yihua;
Wu, Yidong

Publication type:

Article

Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility.

Published in:

Human Reproduction Open, 2024, v. 2024, n. 2, p. 1, doi. 10.1093/hropen/hoae020

By:

Olszewska, Marta;
Malcher, Agnieszka;
Stokowy, Tomasz;
Pollock, Nijole;
Berman, Andrea J;
Budkiewicz, Sylwia;
Kamieniczna, Marzena;
Jackowiak, Hanna;
Suszynska-Zajczyk, Joanna;
Jedrzejczak, Piotr;
Yatsenko, Alexander N;
Kurpisz, Maciej

Publication type:

Article

Advances and Obstacles in Using CRISPR/Cas9 Technology for Non-Coding RNA Gene Knockout in Human Mesenchymal Stromal Cells.

Published in:

Non-Coding RNA, 2023, v. 9, n. 5, p. 49, doi. 10.3390/ncrna9050049

By:

Basalova, Nataliya;
Illarionova, Maria;
Skryabina, Mariya;
Vigovskiy, Maksim;
Tolstoluzhinskaya, Anastasia;
Primak, Alexandra;
Chechekhina, Elizaveta;
Chechekhin, Vadim;
Karagyaur, Maxim;
Efimenko, Anastasia

Publication type:

Article

Involvement of the Methyltransferase CcLaeA in Regulating Laccase Production in Curvularia clavata J1.

Published in:

Fermentation (Basel), 2025, v. 11, n. 4, p. 178, doi. 10.3390/fermentation11040178

By:

Pi, Changyu;
Li, Jinyang;
Jiang, Fangting;
Zhang, Jintong;
Bao, Tongtong;
Zhao, Shengguo;
Chen, Guoshun

Publication type:

Article

Characterization of the Key Aroma Compounds of Soybean Flavor in Fermented Soybeans with Bacillus subtilis BJ3-2 by Gene Knockout, Gas Chromatography–Olfactometry–Mass Spectrometry, and Aroma Addition Experiments.

Published in:

Fermentation (Basel), 2024, v. 10, n. 8, p. 409, doi. 10.3390/fermentation10080409

By:

Chen, Zhaofeng;
Wu, Yongjun;
Tong, Shuoqiu;
Jin, Jing;
Zhang, Lincheng;
Li, Chen;
Tan, Qibo;
Wen, Feng;
Tao, Yi

Publication type:

Article

The Influence of Trctf1 Gene Knockout by CRISPR–Cas9 on Cellulase Synthesis by Trichoderma reesei with Various Soluble Inducers.

Published in:

Fermentation (Basel), 2023, v. 9, n. 8, p. 746, doi. 10.3390/fermentation9080746

By:

Chen, Yudian;
Gao, Yushan;
Wang, Zancheng;
Peng, Nian;
Ran, Xiaoqin;
Chen, Tingting;
Liu, Lulu;
Li, Yonghao

Publication type:

Article

New Insights on Low-Temperature Fermentation for Food.

Published in:

Fermentation (Basel), 2023, v. 9, n. 5, p. 477, doi. 10.3390/fermentation9050477

By:

Liang, Chen;
Liu, Ling-Xiao;
Liu, Jun;
Aihaiti, Aihemaitijiang;
Tang, Xiao-Juan;
Liu, Yun-Guo

Publication type:

Article

Unveiling the Effect of NCgl0580 Gene Deletion on 5-Aminolevulinic Acid Biosynthesis in Corynebacterium glutamicum.

Published in:

Fermentation (Basel), 2023, v. 9, n. 3, p. 213, doi. 10.3390/fermentation9030213

By:

Wu, Jian;
Jiang, Meiru;
Kong, Shutian;
Hong, Kunqiang;
Zhao, Juntao;
Sun, Xi;
Cui, Zhenzhen;
Chen, Tao;
Wang, Zhiwen

Publication type:

Article

High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availability.

Published in:

GeroScience, 2021, v. 43, n. 2, p. 941, doi. 10.1007/s11357-020-00265-2

By:

Santos, Sean M.;
Laflin, Samantha;
Broadway, Audrie;
Burnet, Cosby;
Hartheimer, Joline;
Rodgers, John;
Smith, Daniel L.;
Hartman IV, John L.

Publication type:

Article

哈维弧菌vhh 基因缺失株的构建及其相关生物学特性研究.

Published in:

South China Fisheries Science, 2020, v. 16, n. 2, p. 43, doi. 10.12131/20190211

By:

张亚秋;
邓益琴;
冯娟;
毛灿;
胡建美;
苏友禄

Publication type:

Article

组蛋白赖氨酸甲基转移酶 CfDot1 在果生刺盘孢中的功能.

Published in:

Mycosystema, 2025, v. 44, n. 2, p. 240194-1, doi. 10.13346/j.mycosystema.240194

By:

范晶晶;
李冠辰;
王子瑄;
李河

Publication type:

Article

果生刺盘孢 G 蛋白信号调控因子 CfRGS4 基因的生物学功能.

Published in:

Mycosystema, 2024, v. 43, n. 8, p. 1, doi. 10.13346/j.mycosystema.240077

By:

胡秋月;
曹凌雪;
李河

Publication type:

Article

膨大弯颈霉中与 Bmt生物合成相关的 PKS基因功能研究.

Published in:

Mycosystema, 2023, v. 42, n. 8, p. 1691, doi. 10.13346/j.mycosystema.220487

By:

杨秀青;
李丝竹;
徐康;
刘美洁;
郭立忠;
于浩

Publication type:

Article

多主棒孢 CcCas2 基因纯合敲除突变体构建及致病功能.

Published in:

Mycosystema, 2023, v. 42, n. 8, p. 1701, doi. 10.13346/j.mycosystema.220442

By:

侯梦圆;
武海燕;
何雨芯;
郭雅双;
耿月华;
臧睿;
张猛;
徐超

Publication type:

Article

组蛋白去乙酰化酶 CfSnt2 调控果生刺盘孢生长发育和致病力.

Published in:

Mycosystema, 2022, v. 41, n. 6, p. 926, doi. 10.13346/j.mycosystema.210364

By:

陈振宏;
李河;
陈嘉怡;
陈晓迪;
罗晶;
张盛培

Publication type:

Article

烟曲霉 FADB 基因参与菌株耐药的潜在机理.

Published in:

Mycosystema, 2022, v. 41, n. 4, p. 561, doi. 10.13346/j.mycosystema.210326

By:

刘璐摇;
廖魏祖;
张恒;
高露娟;
李琳芸;
孙毅

Publication type:

Article

甘蔗鞭孢堆黑粉菌原生质体转化 DNA 双片段的基因敲除方法的建立.

Published in:

Mycosystema, 2020, v. 39, n. 12, p. 2314, doi. 10.13346/j.mycosystema.200273

By:

蔡恩平;
梅丹;
张小萌;
孙贤;
李玲玉;
吴熔熔;
邓懿祯;
姜子德;
常长青

Publication type:

Article

白念珠菌基因功能研究的策略.

Published in:

Mycosystema, 2020, v. 39, n. 11, p. 2149, doi. 10.13346/j.mycosystema.200202

By:

吕权真;
张景翔;
姜远英;
王彦

Publication type:

Article

新型隐球菌临床菌株中CNAG_01032 基因的鉴定和功能研究.

Published in:

Mycosystema, 2019, v. 38, n. 8, p. 1341, doi. 10.13346/j.mycosystema.190057

By:

邱文;
兰咏哲;
王迪;
黄劲;
廖万清;
康颖倩

Publication type:

Article

Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01923-6

By:

Liu, Wuming;
Ren, Yifan;
Wang, Tao;
Wang, Mengzhou;
Xu, Yujia;
Zhang, Jia;
Bi, Jianbin;
Wu, Zheng;
Zhang, Yuanyuan;
Wu, Rongqian

Publication type:

Article

Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01851-5

By:

Liu, Rongrong;
Shang, Wenjing;
Liu, Yingying;
Xie, Yi;
Luan, Jun;
Zhang, Ting;
Ma, Ying;
Wang, Zengxian;
Sun, Yan;
Song, Xicheng;
Han, Fengchan

Publication type:

Article