We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genoprotective Potency of Vit C on Zinc Oxide (ZnO) and Iron Oxide (Fe<sub>2</sub>O<sub>3</sub>) Nanoparticle-Mediated Toxicity, an In Vitro Study.
- Authors
Karimi, Arezoo; Modanloo, Mona; Barghi, Nasrin Ghassemi; Shokrzadeh, Mohammad
- Abstract
Introduction: The potential of zinc oxide (ZnO) and iron oxide (Fe2O 3) nanoparticles (NPs) to induce toxic effects, especially genotoxicity, has been demonstrated in previous studies and is in part related to the ability of NPs to produce ROS. The use of antioxidants is an effective method to reduce NP-induced genotoxicity. The aim of this study was to determine the protective role of vitamin C as a potent antioxidant in ZnO-and Fe2O3 NP-induced genotoxicity in the HGF-1 cell line. Methods: Different concentrations of ZnO and Fe2O3 NPs (50 μ g, 100 μ g, and 150 μ g/mL) were used to achieve the best concentration for further evaluation. HGF-1 cells were incubated with different concentrations of vitamin C 24 h before the NPs. The cells were then exposed to ZnO and Fe2O3 NPs at a concentration of 100 μ g/mL for 1 h. The possible genoprotective effects of vitamin C were determined using a comet assay. Results: The results of this study showed that all concentrations of vitamin C could reduce the DNA damage induced by ZnO and Fe2O3 NPs. Discussion: In conclusion, vitamin C could be considered a potent genoprotective agent against ZnO- and Fe2O3 NP-induced genotoxicity.
- Subjects
VITAMIN C; POISONS; FERRIC oxide; DNA damage; GENETIC toxicology
- Publication
International Journal of Nanoscience, 2024, Vol 23, Issue 5, p1
- ISSN
0219-581X
- Publication type
Academic Journal
- DOI
10.1142/S0219581X24500017