Results
Title

The Traditional Applications, Phytochemistry, Pharmacology, Pharmacokinetics, Quality Control and Safety of Paeoniae Radix Alba: A Review.

Authors

Mu, Xiangyu; Luan, Ruqiao; Gao, Yan; Zhao, Bonian; Wang, Jieqiong; Ni, Xinran; Gao, Dongmei

Abstract

Paeoniae Radix Alba (PRA, called Baishao in China) is the dried root of Paeonia lactiflora Pall. In clinical practice, PRA has been used to treat cardiovascular disease, menstrual disorders, abdominal pain, diarrhea, and liver disease, among other conditions. This review provides a systematic summary of its traditional uses, geographical distribution and current cultivation situation, phytochemistry, pharmacokinetics, pharmacology, quality control, and toxicology. Moreover, this review also serves as an in-depth discussion on the shortcomings of the current research on PRA, a subject not previously discussed in reviews regarding PRA, and puts forward its own views and solutions. So far, more needs to be done to understand the mechanism of action of PRA, as well as the relationships between its chemical components and their potential synergistic and antagonistic effects. Furthermore, a comprehensive evaluation of medicinal quality should be carried out to understand the long-term in vivo toxicity and clinical efficacy of PRA and to provide more information for the development of new drugs and treatment methods for various diseases using PRA and its chemical components.

Subjects

CHINA; LIVER disease prevention; CHINESE medicine; DRUG toxicity; ANTI-inflammatory agents; PATIENT safety; PHENOMENOLOGICAL biology; HERBAL medicine; TOXICOLOGY; ANTINEOPLASTIC agents; PLANT roots; PHYTOCHEMICALS; BIOCHEMISTRY; IMMUNE system; MEDICINAL plants; MOLECULAR structure; ANTIOXIDANTS; DRUG development; DRUG synergism; PHARMACOKINETICS; THERAPEUTICS

Publication

American Journal of Chinese Medicine, 2024, Vol 52, Issue 8, p2337

ISSN

0192-415X

Publication type

Academic Journal

DOI

10.1142/S0192415X24500897