Efficacy of Oriental Exercises for Non-Motor Symptoms and Quality of Life in Parkinson's Disease: A Systematic Review and Meta-Analysis.

Peng, Wanqing; Zhao, Renhui; Huang, Ziting; Zhou, Jingpei; Sun, Quan; Li, Ziyuan; Li, Xinyu; Yu, Jinyan; Wang, Nanbu; Chen, Zhenhu

Parkinson's disease (PD) is a progressive neurodegenerative disorder without a definitive cure. Oriental exercises (OEs) have emerged as a complementary and alternative therapy for PD, but their efficacy in ameliorating non-motor symptoms (NMS) and quality of life (QOL) remains uncertain. This systematic review and meta-analysis actively investigated the efficacy of OEs in addressing NMS and enhancing QOL and sought to offer recommendations for optimal OE regimens for PD patients. By analyzing 30 controlled trials involving 2029 participants, we found that OEs significantly improved cognitive function, neuropsychiatric symptoms, and QOL compared to control groups. Specifically, significant improvements were observed in several outcome measures: Parkinson's Disease Questionnaire (PDQ) [MD: − 3.67, 95% CI: − 5.72– − 1.63, P < 0. 0 0 0 0 1 , I 2 = 7 5 %], Parkinson's Disease Non-Motor Symptom Questionnaire (NMSQ) [MD: − 2.34, 95% CI: − 4.67– − 0.01, P = 0. 0 5 , I 2 = 9 1 %], Montreal Cognitive Assessment (MoCA) [MD: 1.75, 95% CI: 1.46–2.03, P < 0. 0 0 0 0 1 , I 2 = 0 %], Stroop Color and Word Test (SCWT) [MD: 0.87, 95% CI: 0.49–1.24, P < 0. 0 0 0 0 1 , I 2 = 0 %], Frontal Assessment Battery (FAB) [MD: 1.49, 95% CI: 1.16–1.81, P < 0. 0 0 0 0 1 , I 2 = 2 8 %], Hamilton Depression Scale (HAMD) [MD: − 4.27, 95% CI: − 6.85– − 1.69, P = 0. 0 0 1 , I 2 = 9 9 %], Hamilton Anxiety Scale (HAMA) [MD: − 0.24, 95% CI: − 0.32– − 0.16, P < 0. 0 0 0 0 1 , I 2 = 0 %], and the Symptom Checklist-90 (SCL-90) [MD: − 0.37, 95% CI: − 0.48– − 0.25, P < 0. 0 0 0 0 1 , I 2 = 0 %]. Our findings provide compelling evidence for the potential benefits of OEs in managing NMS and improving QOL in PD patients. To optimize outcomes, we recommend customizing OE regimens based on individual clinical phenotypes, and to validate these results we emphasize the need for rigorous, large-scale studies.

CHINESE medicine; MEDICAL information storage & retrieval systems; STATISTICAL models; EXERCISE therapy; EXECUTIVE function; SYMPTOMS; PARKINSON'S disease; TREATMENT effectiveness; META-analysis; DESCRIPTIVE statistics; SYSTEMATIC reviews; MEDLINE; QUALITY of life; MEDICAL databases; ONLINE information services; DATA analysis software; CONFIDENCE intervals; SLEEP quality; COGNITION

American Journal of Chinese Medicine, 2024, Vol 52, Issue 8, p2233

0192-415X

Academic Journal

10.1142/S0192415X24500861