Title: The level of cytokines and expression of caspase genes in rheumatoid arthritis.
Authors: Malysheva, I.; Topchieva, L.; Barysheva, O.; Kurbatova, I.; Vasykova, O.; Vezikova, N.; Marusenko, I.; Nemova, N.
Abstract: The level of TNFα and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients without MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the RA patients with MT therapy compared to the patients without MT therapy.
Subjects: CYTOKINES; RHEUMATOID arthritis; BLOOD plasma; ANTI-inflammatory agents; METHOTREXATE; LYMPHOCYTES
Publication: Doklady Biochemistry & Biophysics, 2016, Vol 468, Issue 1, p226
ISSN: 1607-6729
Publication type: Academic Journal
DOI: 10.1134/S1607672916030194

The level of cytokines and expression of caspase genes in rheumatoid arthritis.

Malysheva, I.; Topchieva, L.; Barysheva, O.; Kurbatova, I.; Vasykova, O.; Vezikova, N.; Marusenko, I.; Nemova, N.