Title: Pattern of proteasome expression in Walker 256 tumor cells after their transplantation into the Brattleboro rats with genetic defect of vasopressin synthesis.
Authors: Sharova, N. P.; Mel'nikova, V. I.; Khegai, I. I.; Karpova, Ya. D.; Dmitrieva, S. B.; Astakhova, T. M.; Afanas'eva, M. A.; Popova, N. A.; Ivanova, L. N.; Zakharova, L. A.
Abstract: The article presents a study on the dynamics of proteasomes in WALKER 256 tumors cells grafted into the Brattleboro rats and Wistar albino Glaxo (WAG) rats. The proteasome subunits and the activators were determined by immunoblotting, assessed using antibodies and processed statistically. The study shows that the total pool of proteasomes in the Brattleboro rats were reduced and led to tumor regression while tumor cells in WAG rats intensely grew and escaped immune control.
Subjects: COMPARATIVE studies; TUMOR growth prevention; BRATTLEBORO rat; IMMUNOBLOTTING; EXPERIMENTAL oncology; LABORATORY rats
Publication: Doklady Biochemistry & Biophysics, 2008, Vol 419, Issue 1, p93
ISSN: 1607-6729
Publication type: Academic Journal
DOI: 10.1134/S1607672908020129

Pattern of proteasome expression in Walker 256 tumor cells after their transplantation into the Brattleboro rats with genetic defect of vasopressin synthesis.

Sharova, N. P.; Mel'nikova, V. I.; Khegai, I. I.; Karpova, Ya. D.; Dmitrieva, S. B.; Astakhova, T. M.; Afanas'eva, M. A.; Popova, N. A.; Ivanova, L. N.; Zakharova, L. A.