Design, Synthesis, and Anticancer Evaluation of N-(4-{5-[4-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl]-4-(2,3,4-trimethoxyphenyl)-1,3-thiazol-2-yl}phenyl)benzamides.

Ravinaik, B.; Rao, M. V. B.; Rao, P. T. S. R. K. P.; Ramachandran, D.; Reddy, D. R. S.

A series of substituted N-(4-{5-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-4-(2,3,4-trimethoxy-phenyl)-1,3-thiazol-2-yl}phenyl)benzamides were designed and synthesized starting from 2-(4-methylphenyl)acetic acid, 1,2,3-trimethoxybenzene, and substituted benzoyl chlorides. The synthesized compounds were evaluated for anticancer activity against four cancer cell lines: MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer). Most of the tested compounds exhibited moderate to excellent anticancer activity in comparison to etoposide used as reference drug with the IC50 values ranging from 0.013±0.001 to 17.38±6.43 µM against 0.17±0.034 to 3.34±0.152 µM for etoposide. Five derivatives showed higher anticancer activities than the reference drug.

BENZAMIDE; BREAST cancer; THIADIAZOLES; BENZOYL chloride; LUNG cancer; ACETIC acid

Russian Journal of Organic Chemistry, 2021, Vol 57, Issue 4, p624

1070-4280

Academic Journal

10.1134/S1070428021040187