Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives.

Lalpara, J. N.; Vachhani, M. D.; Hadiyal, S. D.; Goswami, S.; Dubal, G. G.

A series of N-substituted-6-methyl-4-{4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxyphenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides have been synthesized by the condensation of newly synthesized {4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol. The synthesized compounds have been characterized by 1H, 13C NMR, IR spectroscopy, and mass spectrometry. All synthesized compounds were evaluated for in vitro antidiabetic activity using the α-amylase inhibition assay with the 3,5-dinitrosalicylic acid (DNSA) reagent.

HYPOGLYCEMIC agents; CHEMICAL synthesis; MASS spectrometry; THIADIAZOLES; AROMATIC aldehydes

Russian Journal of Organic Chemistry, 2021, Vol 57, Issue 2, p241

1070-4280

Academic Journal

10.1134/S1070428021020159