EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives.

Authors

Lalpara, J. N.; Vachhani, M. D.; Hadiyal, S. D.; Goswami, S.; Dubal, G. G.

Abstract

A series of N-substituted-6-methyl-4-{4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxyphenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides have been synthesized by the condensation of newly synthesized {4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol. The synthesized compounds have been characterized by 1H, 13C NMR, IR spectroscopy, and mass spectrometry. All synthesized compounds were evaluated for in vitro antidiabetic activity using the α-amylase inhibition assay with the 3,5-dinitrosalicylic acid (DNSA) reagent.

Subjects

HYPOGLYCEMIC agents; CHEMICAL synthesis; MASS spectrometry; THIADIAZOLES; AROMATIC aldehydes

Publication

Russian Journal of Organic Chemistry, 2021, Vol 57, Issue 2, p241

ISSN

1070-4280

Publication type

Academic Journal

DOI

10.1134/S1070428021020159

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved