Title: Synthesis and Antibacterial Activity of New Oxadiazolylbenzodioxane Derivatives.
Authors: Avagyan, A. S.; Vardanyan, S. O.; Sargsyan, A. B.; Aghekyan, A. A.; Panosyan, H. A.; Paronikyan, R. V.; Stepanyan, H. M.; Muradyan, R. E.
Abstract: Reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol with N-substituted chloroacetamides gave a series of the corresponding derivatives at the sulfur atom. Addition reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol to the C=C double bond of acrylonitrile, acrylamide, and ethyl acrylate, as well as Mannich condensation with morpholine and piperidine, were studied. The synthesized compounds were evaluated for their antibacterial activity.
Subjects: ETHYL acrylate; CHLOROACETAMIDES; ADDITION reactions; DOUBLE bonds; ACRYLAMIDE; THIADIAZOLES; MORPHOLINE
Publication: Russian Journal of Organic Chemistry, 2020, Vol 56, Issue 3, p385
ISSN: 1070-4280
Publication type: Academic Journal
DOI: 10.1134/S1070428020030033

Synthesis and Antibacterial Activity of New Oxadiazolylbenzodioxane Derivatives.

Avagyan, A. S.; Vardanyan, S. O.; Sargsyan, A. B.; Aghekyan, A. A.; Panosyan, H. A.; Paronikyan, R. V.; Stepanyan, H. M.; Muradyan, R. E.