Title: New approach to the synthesis of macrocyclic core of cytotoxic lactone ( )-neopeltolide. Synthesis of C-C segment basing on cyclopropanol intermediates.
Authors: Mineeva, I.
Abstract: A new retrosynthetic procedure was developed for the synthesis of the macrocyclic core of a cytotoxic lactone ( )-neopeltolide utilizing cyclopropanol intermediates. The synthesis was suggested and carried out of the C-C segment of ( )-neopeltolide to obtain (4 S,6 S)-6-[(2 S)-2-hydroxypentyl]-4-methyltetrahydro-2 H-pyran-2-one. The possibility was demonstrated of a formal synthesis based on the obtained product of the potential antitumor pharmaceutical ( )-neopeltolide.
Subjects: CHEMICAL synthesis; LACTONES; MACROCYCLIC compounds; CYCLOPROPANOL; CLICK chemistry
Publication: Russian Journal of Organic Chemistry, 2015, Vol 51, Issue 8, p1061
ISSN: 1070-4280
Publication type: Academic Journal
DOI: 10.1134/S1070428015080023

New approach to the synthesis of macrocyclic core of cytotoxic lactone ( )-neopeltolide. Synthesis of C-C segment basing on cyclopropanol intermediates.

Mineeva, I.