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Title

New approach to the synthesis of macrocyclic core of cytotoxic lactone ( )-neopeltolide. Synthesis of C-C segment basing on cyclopropanol intermediates.

Authors

Mineeva, I.

Abstract

A new retrosynthetic procedure was developed for the synthesis of the macrocyclic core of a cytotoxic lactone ( )-neopeltolide utilizing cyclopropanol intermediates. The synthesis was suggested and carried out of the C-C segment of ( )-neopeltolide to obtain (4 S,6 S)-6-[(2 S)-2-hydroxypentyl]-4-methyltetrahydro-2 H-pyran-2-one. The possibility was demonstrated of a formal synthesis based on the obtained product of the potential antitumor pharmaceutical ( )-neopeltolide.

Subjects

CHEMICAL synthesis; LACTONES; MACROCYCLIC compounds; CYCLOPROPANOL; CLICK chemistry

Publication

Russian Journal of Organic Chemistry, 2015, Vol 51, Issue 8, p1061

ISSN

1070-4280

Publication type

Academic Journal

DOI

10.1134/S1070428015080023

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