Cyclopropanol methodology in the synthesis of (4 R)- and (4 S)-4-methyltetrahydro-2 H-pyran-2-ones. Application in the synthesis of insect pheromones with methyl-branched carbon skeleton.
A number of chiral methyl-branched building blocks have been synthesized starting from (4 S)-4-methyltetrahydro-2 H-pyran-2-one, and the possibility for using them for the preparation of mealworm beetle, rhinoceros beetle, and earth-boring dung beetle pheromones and many other biologically active compounds has been demonstrated.