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- Title
New transformations of 3-acetyl-5-(alkoxymethyl)tetrahydrofuran-2-ones.
- Authors
Ghochikyan, T.; Harutyunyan, V.; Samvelyan, M.; Harutyunyan, E.
- Abstract
Alkylation of 3-acetyl-5-(alkoxymethyl)tetrahydrofuran-2-ones gave 3-acetyl-5-(alkoxymethyl)-tetrahydrofuran-2-ones containing various substituents in position 3 of the heterocycle. Bromination of the latter afforded 3-(bromoacetyl) derivatives which reacted with various nucleophiles to produce derivatives containing benzimidazole, 2-amino-1,3-thiazole, 3-chloropyridine, and 3,5-dibromopyridine fragments together with the butanolide ring.
- Subjects
ALKYLATION; TETRAHYDROFURAN; HETEROCYCLIC compounds synthesis; ALKYL bromides; LACTONES; ORGANIC synthesis; SPECTRUM analysis; NUCLEOPHILES; ACETONE
- Publication
Russian Journal of Organic Chemistry, 2014, Vol 50, Issue 10, p1456
- ISSN
1070-4280
- Publication type
Academic Journal
- DOI
10.1134/S1070428014100108